Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
366 participants
OBSERVATIONAL
2022-12-07
2027-07-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Efficacy of Immunosuppressive Therapy for IgA Nephropathy With Stage 3 or 4 CKD
NCT05510323
The Efficacy of Prednisone and Combination Therapy With Methylprednisolone and Cyclophosphamide on IMN in Stage I.
NCT03466801
Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy
NCT02662283
Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency
NCT04020328
Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy
NCT01758120
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
1. Is the apparent benefit of glucocorticoid sustained over long term follow-up?
2. Does a lower dose of steroids safely produce similar benefits on long-term kidney outcomes?
The primary aim of TESTING-ON is to extend follow up of TESTING study participants and to assess the long-term effects of a 6-9-month course of oral methylprednisolone on end stage kidney disease (ESKD), according to dose (full-dose vs reduced-dose), ethnicity (Chinese vs other) and kidney function (eGFR above and below 60 mL/min/1.73m2).
The working hypothesis of TESTING-ON is that a 6-9-month course of oral methylprednisolone will lead to persistent benefits over a long period of time.
TESTING-ON is a post-trial observational study of those participants randomized into the TESTING trial who are still alive, haven't reached ESKD and didn't withdraw consent during the trial. Follow-up will continue for up to five years, with further ongoing follow-up should funding allow.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
TESTING Particpants
All participants who were successfully randomised to the TESTING study who are still alive and have not reached kidney failure requiring dialysis.
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
2. Participants who died during the TESTING trial
3. Participants who had withdrawn their consent during the TESTING trial
4. Participants who are unable to provide consent for some other reason
18 Years
100 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Peking University Institute of Nephrology
UNKNOWN
The George Institute
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Hong Zhang, Prof
Role: STUDY_CHAIR
Peking University Institute of Nephrology
Vlado Perkovic, Prof
Role: STUDY_CHAIR
University of New South Wales
Muh Geot Wong, Dr
Role: PRINCIPAL_INVESTIGATOR
University of New Souht Wales
Jicheng Lv
Role: PRINCIPAL_INVESTIGATOR
Peking University of Nephrology
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Nepean Hospital
Kingswood, New South Wales, Australia
Royal North Shore Hospital
St Leonards, New South Wales, Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia
University of Calgary/Alberta Health Services
Calgary, Alberta, Canada
University of Alberta Hospitals
Edmonton, Alberta, Canada
St Pauls Hospital
Vancouver, British Columbia, Canada
St. Joseph's Healthcare
Hamiliton, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Toronto General Hospital,
Toronto, Ontario, Canada
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Chinese PLA General Hospital (301 Hospital)
Beijing, Beijing Municipality, China
The First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
Guangdong Provincial People's Hospital, Guangzhou
Guangzhou, Guangdong, China
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Renmin Hospital, Wuhan University
Wuhan, Hubei, China
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology,
Baotou, Inner Mongolia, China
Inner Mongolia People's Hospital
Hohhot, Inner Mongolia, China
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China
Jilin Province FAW General Hospital [Jilin University Fourth Hospital]
Changchun, Jilin, China
he First Affiliated Hospital of Dalian Medical University, Dalian
Dalian, Liaoning, China
Shengjing Hospital Of China Medical University
Shengyang, Liaoning, China
Qilu Hospital of Shandong University
Jinan, Shandong, China
The First Affiliated Hospital of Shangdong First Medical University,Shangdong Provincial Qianfoshin
Jinan, Shandong, China
Shandong Provincial Hospital
Jinan, Shandong, China
Jinan Military General Hospital
Jinan, Shandong, China
The Second Hospital of Shanxi Medical University, Taiyuan
Taiyuan, Shanxi, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
The First Affiliated Hospital, Zhejiang University of Medicine
Hangzhou, Zhejiang, China
Hangzhou Hospital of Traditional Chinese Medicine,
Hangzhou, Zhejiang, China
Ningbo Urology & Nephrology Hospital
Ningbo, Zhejiang, China
Zhejiang Provincial People's Hospital
Sangzhou, Zhejiang, China
Beijing Anzhen Hospital, Capital Medical University
Beijing, , China
Peking University First Hospital
Beijing, , China
Peking University People's Hospital
Beijing, , China
Peking University Third Hospital
Beijing, , China
XinQiao Hospital, Third Military Medical University
Chongqing, , China
Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, , China
Ruijin Hospital, Shanghai Jiaotong University, School of Medicine
Shanghai, , China
Princess Margaret Hospital
Kowloon, , Hong Kong
Osmania General Hospital
Hyderabad, Andhra Pradesh, India
Nizams Institute of Medical Sciences
Hyderabad, Andhra Pradesh, India
Calicut Medical College
Kozhikode, Kerala, India
Post Graduate Institue of Medical Education and Reasearch
Chandigarh, Punjab, India
Madras Medical College
Chen, Tamil Nadu, India
Hospital Sultanah Aminah
Johor Bahru, Johor, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, Kulala Lumpur, Malaysia
Hospital Tuanku Jaafar Seremban
Seremban, Negri Seremban, Malaysia
Hospital Raja Permaisuri Bainun
Ipoh, Perak, Malaysia
Hospital Umum Sarawak
Kuching, Samarahan, Malaysia
University Malaysia Medical Centre
Kuala Lumpur, , Malaysia
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
TESTING-ON
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.