Prednisolone Treatment in Acute Interstitial Nephritis

NCT ID: NCT04376216

Last Updated: 2020-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2027-09-01

Brief Summary

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A Prospective randomized trial with a primary objective to investigate the effect ofprdenisolone treatment in acute interstitial nephritis

Detailed Description

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Conditions

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Acute Tubulo-Interstitial Nephritis

Keywords

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Acute Tubulo-Interstitial Nephritis Prednisone

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

No treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Prednisone

Oral prednisone. Starting dose of 60 mg with tapering for 2 months

Group Type ACTIVE_COMPARATOR

Prednisone

Intervention Type DRUG

60 mg with dose tapering over 2 months

Interventions

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Prednisone

60 mg with dose tapering over 2 months

Intervention Type DRUG

Other Intervention Names

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Prednisolone

Eligibility Criteria

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Inclusion Criteria

* Biopsy verified AIN
* Clinical suspicion of AIN
* Age \> 18 years
* One of following criteria:

* Plasma creatinine \> 120 µmol/L or
* Plasma creatinine increase \> 30 µmol/L or increase \> 50 % of baseline plasma creatinine
* Fertile women are included

Exclusion Criteria

* No ability to give informed consent
* Immunosuppressive treatment (including prednisolone) within 3 months before biopsy
* Autoimmune disease
* Prednisolone intolerance
* Pregnancy or lactation
* Active cancer (except basal cell carcinoma)
* Short life expectancy (\< 6 months)
* CKD stage IV-V
* AIN secondary to or accompanied by glomerulonephritis, sarcoidosis or inherited interstitial renal disease
* Previous participation Withdrawal criteria
* Development of exclusion criterion
* Withdrawal of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

Region MidtJylland Denmark

OTHER

Sponsor Role lead

Responsible Party

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Frank Mose

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jesper N Bech, MD

Role: STUDY_CHAIR

Region MidtJylland Denmark

Locations

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Godstrup Hospital

Herning, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Frank Mose, MD

Role: CONTACT

Phone: +4528531257

Email: [email protected]

Facility Contacts

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Frank Mose

Role: primary

References

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Mose FH, Birn H, Hoffmann-Petersen N, Bech JN. Prednisolone treatment in acute interstitial nephritis (PRAISE) - protocol for the randomized controlled trial. BMC Nephrol. 2021 May 1;22(1):161. doi: 10.1186/s12882-021-02372-4.

Reference Type DERIVED
PMID: 33933012 (View on PubMed)

Other Identifiers

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FHM-1-2017

Identifier Type: -

Identifier Source: org_study_id