Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
NCT ID: NCT01750723
Last Updated: 2013-07-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2012-12-31
2013-04-30
Brief Summary
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Detailed Description
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With magnetic resonance imaging the investigators will investigate changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), diameter of MCA, the Internal carotic artery (ICA), the superficial temporal artery (STA) and the Medial Meningeal artery (MMA).
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Acetazolamide
Acetazolamide 1 g in 10 ml saline, i.v. infusion
Acetazolamide
1 g diluted in 10 ml saline, i.v. bolus injection.
Saline
Saline, 10 ml i.v. infusion
No interventions assigned to this group
Interventions
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Acetazolamide
1 g diluted in 10 ml saline, i.v. bolus injection.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Aged 18-40
* 50-100 kg
* Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.
Exclusion Criteria
* Other primary headaches
* Daily medication except contraceptives
* Drug taken within 4 times the halflife for the specific drug except contraceptives
* Pregnant or lactating women
* Exposure to radiation within the last year
* Headache within the last 24 hours before start of trial
* Hypertension
* Hypotension
* Respiratory or cardiac disease
18 Years
50 Years
ALL
Yes
Sponsors
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Danish Headache Center
OTHER
Responsible Party
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Nanna Arngrim
MD, medical doctor
Principal Investigators
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Nanna Arngrim, MD
Role: PRINCIPAL_INVESTIGATOR
Danish Headache Center
Locations
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Danish Headache Center
Copenhagen, Glostrup, Denmark
Department of Neurology
Copenhagen, Glostrup, Denmark
Countries
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Other Identifiers
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H-3-2012-137
Identifier Type: -
Identifier Source: org_study_id
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