Comparison of Ultrafast Echo With Echotracking

NCT ID: NCT01743352

Last Updated: 2015-10-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 57 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-03-31
• Study Completion Date: 2015-08-31

Brief Summary

The aim is to compare a new technique for assessing mechanical properties of large arteries: the Ultrafast echo with the reference technique, the echotracking. This will be done by studying in parallel hypertensive patients and controls with both techniques and this will revisit old concepts of increased stiffness in hypertensive arteries.

Detailed Description

Ultrafast ECHO is a new non invasive method for assessing stiffness of living tissues. It takes advantage of very fast imaging technologies (up to 20 000 images/sec) to measure the diffusion of pressure waves in the tissues. This pressure wave can be either natural (blood pressure), or generated by an very short ultrasonic impulsion at a given place. By using both modes, it is possible to have a precise cartography of tissue mechanical properties. This technique is applied to solid tissues such as breast or liver, but not yet currently to hollow tissues such as arteries. The aim of the present study is to compare the values of stiffness obtained with Ultrafast ECHO with the reference non invasive technique, the Echotracking, which measures stiffness by assessing the deformation of arteries in response to changes in blood pressure. On the physiological part, we will revisit old concepts of increased stiffness of hypertensive's arteries. Indeed, hypertension is associated with increased stiffness due to recruitement of collagen fibers, but also to chronic remodelling. We have shown before that this remodelling conducts to accumulation of arterial tissue of lesser intrinsic stiffness. The latter finding was done through models based on echotracking measurements. It will be interesting to see whether it holds true when stiffness is directly measured.

Sixty subjects (30 normotensive and30 hypertensives) will be included and studied once. Measurement will be performed in random order 3 time on the common carotid artery on both sides. Aortic stiffness will be measured by pulse wave velocity

Conditions

Essential Untreated Hypertension; Healthy Volunteers

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Hypertension patients

Local common carotid artery pulse wave velocity is compared in patients with hypertension and healthy volunteers.

No interventions assigned to this group

Healthy Volunteers

Local common carotid artery pulse wave velocity is compared in hypertension patients and healthy volunteers

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• hypertension,
• essential (WHO workup),
• untreated (> 28 days of treatment interruption, < 6 months of treatment) on insufficiently equilibrated (BP > 140 and/or 90 mmHg)

Exclusion Criteria

• Any concomitant severe disease compromising patient's participation or compliance

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

French Cardiology Society

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Stéphane Laurent, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Pharmacology Department - Hopital Européen Georges Pompidou - Paris

Locations

Hopital Européen Georges Pompidou / Service de Pharmacologie

Paris, , France

Countries

France

Other Identifiers

ID - RCB 2012-A01255-38

Identifier Type: OTHER

Identifier Source: secondary_id

2012-01

Identifier Type: -

Identifier Source: org_study_id