Comparison of Pantoprazole and Ranitidine in Dyspepsia

NCT ID: NCT01737840

Last Updated: 2015-07-23

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2013-01-31

Brief Summary

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The H0 hypothesis of the study is there is no difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

Detailed Description

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Dyspepsia is one of the common complaints in emergency department. Proton pomp inhibitors, H2 receptor blockers and anti-acids are common drugs for treating dyspepsia in emergency department. However there is no study in the emergency department comparing the effectiveness of these drugs. So the investigators planned this study which drug is effective in these patients in order to provide a cost-effective treatment in dyspeptic patients.

Conditions

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Dyspepsia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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pantoprazole

Intravenous pantoprazole 40 mg flacon

Group Type EXPERIMENTAL

Pantoprazole

Intervention Type DRUG

33 patients

ranitidine

Intravenous ranitidine 50 mg

Group Type ACTIVE_COMPARATOR

Ranitidine

Intervention Type DRUG

33 patients

Interventions

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Pantoprazole

33 patients

Intervention Type DRUG

Ranitidine

33 patients

Intervention Type DRUG

Other Intervention Names

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Pantpas Ulcuran

Eligibility Criteria

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Inclusion Criteria

* Epigastric pain
* Older than 18 years old

Exclusion Criteria

* Diagnosed as cholecystitis, pancreatitis, myocardial infarction, etc.. at the end of the emergency deparment evaluation period.
* Pregnancy
* Patients with unstable vital signs
* Patients used anti-acid, H2 receptor blockers and proton pomp inhibitors in the last one hour.
* Allergy to H2 receptor blockers and proton pomp inhibitors.
* Patients denied to give inform consent and who are illiterate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Akdeniz University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cenker Eken, Proffesor

Role: STUDY_DIRECTOR

Akdeniz University

Locations

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Akdeniz University

Antalya, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Welling LR, Watson WA. The emergency department treatment of dyspepsia with antacids and oral lidocaine. Ann Emerg Med. 1990 Jul;19(7):785-8. doi: 10.1016/s0196-0644(05)81704-4.

Reference Type BACKGROUND
PMID: 2202240 (View on PubMed)

Related Links

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http://www.akdeniz.edu.tr

The web adress of the organization which this study is conducted.

Other Identifiers

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160

Identifier Type: -

Identifier Source: org_study_id

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