Can Genetic Markers Predict Weight Loss After Gastric By-pass Surgery

NCT ID: NCT01736384

Last Updated: 2020-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2020-02-29

Brief Summary

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There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.

Detailed Description

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Conditions

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Obesity

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Obesity

Gastric bypass surgery and non-obese controls undergoing cholecystectomy

Gastric bypass or cholecystectomy

Intervention Type PROCEDURE

Interventions

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Gastric bypass or cholecystectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* laparoscopic gastric by-pass with BMI greater than 35

Exclusion Criteria

* unable to understand swedish
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Danderyd Hospital

OTHER

Sponsor Role collaborator

Ersta Hospital, Sweden

OTHER

Sponsor Role collaborator

Karolinska University Hospital

OTHER

Sponsor Role collaborator

Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Erik Näslund

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Erik Näslund, Professor

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

Locations

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Karolinska Institutet, Ersta Hospital

Stockholm, , Sweden

Site Status

Karolinska Institutet, Danderyds Hospital

Stockholm, , Sweden

Site Status

Karolinska University Hospital

Stockholm, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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2008/1010-31/3

Identifier Type: -

Identifier Source: org_study_id

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