RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

NCT ID: NCT01719055

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

4800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-11-19

Study Completion Date

2035-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Instructions for Use

\- and -

To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study is a prospective, multi-center, global, post-market study of Boston Scientific neurostimulation systems for pain.

The study treatment will consist of neurostimulation trial therapy with any commercially approved Boston Scientific Corporation neurostimulator for pain. Positive trials, subjects with a successful trial outcome, may progress to permanent implant of a neurostimulation system. Individualization of neurostimulation therapy for pain will be determined according to investigator discretion and site routine care, and in accordance with inclusion and exclusion criteria.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pain

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

stimulation implantable pulse generator back pain chronic pain leg pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Boston Scientific SCS Systems

Subjects permanently implanted with a Boston Scientific neurostimulation systems

neurostimulation system

Intervention Type DEVICE

Trial stimulation period, followed by permanent implant of a neurostimulation system for subjects with a positive trial outcome

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

neurostimulation system

Trial stimulation period, followed by permanent implant of a neurostimulation system for subjects with a positive trial outcome

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Study candidate is scheduled to be trialed, on-label, with a commercially approved Boston Scientific neurostimulation system for pain, per local directions for use
* Signed a valid, IRB/EC-approved informed consent form
* 18 years of age or older

Exclusion Criteria

* Contraindicated for Boston Scientific neurostimulation system
* Currently diagnosed with cognitive impairment, or exhibits any characteristic, that would limit study candidate's ability to assess pain relief or to complete study assessments
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Natalie Bloom Lyons

Role: STUDY_DIRECTOR

Boston Scientific Corporation

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Physicians Research Group, LLC

Phoenix, Arizona, United States

Site Status TERMINATED

Hope Research Institute

Phoenix, Arizona, United States

Site Status TERMINATED

Banner University Medical Center

Tucson, Arizona, United States

Site Status COMPLETED

Comprehensive Pain Management Center

Campbell, California, United States

Site Status TERMINATED

Coastal Research Institute

Carlsbad, California, United States

Site Status TERMINATED

Pain Medicine Associates, Inc.

Fountain Valley, California, United States

Site Status TERMINATED

Metropolitan Pain Management Consultants Inc.

Sacramento, California, United States

Site Status TERMINATED

Huntley Pain Specialists

San Diego, California, United States

Site Status WITHDRAWN

Conejo Pain Specialists

Thousand Oaks, California, United States

Site Status TERMINATED

Denver Back Pain Specialists

Greenwood Village, Colorado, United States

Site Status RECRUITING

South Lake Pain Institute, Inc

Clermont, Florida, United States

Site Status RECRUITING

University of Florida Shands Hospital

Gainesville, Florida, United States

Site Status RECRUITING

Louis J. Raso, MD, PA

Jupiter, Florida, United States

Site Status TERMINATED

Advanced Interventional Pain Management and Research Clinic, Inc.

Miami Gardens, Florida, United States

Site Status TERMINATED

JM Clinical Research

South Miami, Florida, United States

Site Status WITHDRAWN

Tallahassee Neurological Clinic, PA

Tallahassee, Florida, United States

Site Status TERMINATED

Orthopedic Research Foundation

Savannah, Georgia, United States

Site Status TERMINATED

Pain Care, LLC

Stockbridge, Georgia, United States

Site Status WITHDRAWN

Northwestern Memorial Hospital - Neurosurgery Outpatient Clinic

Chicago, Illinois, United States

Site Status TERMINATED

Chicago Anesthesia Pain Specialists

Chicago, Illinois, United States

Site Status TERMINATED

Global Scientific Innovations - Advanced Pain Care Clinic

Evansville, Indiana, United States

Site Status TERMINATED

Summit Research Institute

Fort Wayne, Indiana, United States

Site Status TERMINATED

Goodman Campbell Brain and Spine

Greenwood, Indiana, United States

Site Status WITHDRAWN

American Health Network of Indiana, LLC

Muncie, Indiana, United States

Site Status TERMINATED

Research Medical Center

Lenexa, Kansas, United States

Site Status TERMINATED

Neuroscience Associates of Northern Kentucky

Crestview Hills, Kentucky, United States

Site Status WITHDRAWN

Bux Pain Management

Danville, Kentucky, United States

Site Status TERMINATED

Ochsner Clinic Foundation

New Orleans, Louisiana, United States

Site Status RECRUITING

Willis-Knighton River Cities Clinical Research Center

Shreveport, Louisiana, United States

Site Status RECRUITING

Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Beth Israel Deaconess Medical Center

Brookline, Massachusetts, United States

Site Status RECRUITING

Michigan Pain Specialists

Ann Arbor, Michigan, United States

Site Status RECRUITING

Insight Institute of Neurosurgery & Neuroscience

Flint, Michigan, United States

Site Status TERMINATED

Forest Health Medical Center

Ypsilanti, Michigan, United States

Site Status TERMINATED

Jackson Anesthesia Pain Center, LLC

Jackson, Mississippi, United States

Site Status TERMINATED

Midwest Pain Center

Chesterfield, Missouri, United States

Site Status TERMINATED

Saint Louis Pain Consultants

Chesterfield, Missouri, United States

Site Status TERMINATED

KC Pain Centers

Lee's Summit, Missouri, United States

Site Status TERMINATED

Hope Research Institute

Las Vegas, Nevada, United States

Site Status WITHDRAWN

Albany Medical Center

Albany, New York, United States

Site Status TERMINATED

New York Presbyterian Hospital

New York, New York, United States

Site Status TERMINATED

University of Rochester

Rochester, New York, United States

Site Status TERMINATED

Spine and Skeletal Pain Medicine

Utica, New York, United States

Site Status TERMINATED

Carolinas Research Institute, PLLC

Huntersville, North Carolina, United States

Site Status TERMINATED

Raleigh Neurology Associates, P.A.

Raleigh, North Carolina, United States

Site Status TERMINATED

The Center for Clinical Research, LLC

Winston-Salem, North Carolina, United States

Site Status RECRUITING

Case Western Reserve University

Cleveland, Ohio, United States

Site Status COMPLETED

Ohio State University Medical Center

Columbus, Ohio, United States

Site Status TERMINATED

University of Toledo Medical Center

Toledo, Ohio, United States

Site Status TERMINATED

Pacific Sports and Spine, LLC

Eugene, Oregon, United States

Site Status RECRUITING

Fox Chase Pain Management

Trevose, Pennsylvania, United States

Site Status RECRUITING

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status TERMINATED

Florence Neurosurgery and Spine

Florence, South Carolina, United States

Site Status TERMINATED

PCPMG Clinical Research Unit, LLC

Greenville, South Carolina, United States

Site Status RECRUITING

Channel Research

Pawleys Island, South Carolina, United States

Site Status TERMINATED

Balcones Pain Consultants

Austin, Texas, United States

Site Status TERMINATED

Institute of Precision Pain Medicine

Corpus Christi, Texas, United States

Site Status RECRUITING

Spine Works Institute

North Richland Hills, Texas, United States

Site Status TERMINATED

Spine Team Texas

Rockwall, Texas, United States

Site Status TERMINATED

Precision Spine Care

Tyler, Texas, United States

Site Status TERMINATED

Washington Center for Pain Management

Bellevue, Washington, United States

Site Status TERMINATED

EvergreenHealth Pain Care

Kirkland, Washington, United States

Site Status WITHDRAWN

Swedish Neuroscience Institute

Seattle, Washington, United States

Site Status TERMINATED

West Virginia University Hospitals

Morgantown, West Virginia, United States

Site Status WITHDRAWN

Advanced Pain Management Appleton

Greenfield, Wisconsin, United States

Site Status TERMINATED

CENIT Centro de Neurociencias, Investigacion y Tratamiento

Buenos Aires, , Argentina

Site Status TERMINATED

Interventus Pain Specialists

Auchenflower, , Australia

Site Status WITHDRAWN

Hunter Clinical Research

Broadmeadow, , Australia

Site Status TERMINATED

Hunter Pain Clinic

Broadmeadow, , Australia

Site Status TERMINATED

Green Lizard Science

Claremont, , Australia

Site Status TERMINATED

Sydney Spine and Pain Pty Ltd

Hurstville, , Australia

Site Status TERMINATED

Sunshine Coast Clinical Research

Noosa, , Australia

Site Status TERMINATED

Pain Matrix

Waurn Ponds, , Australia

Site Status TERMINATED

Pain Medicine of South Australia

Wayville, , Australia

Site Status RECRUITING

AZ Sint-Lucas

Ghent, , Belgium

Site Status WITHDRAWN

AZ Delta

Roeselare, , Belgium

Site Status TERMINATED

London Health Sciences Centre

London, , Canada

Site Status TERMINATED

Hopital de Enfant-Jesus

Québec, , Canada

Site Status ACTIVE_NOT_RECRUITING

Regina General Hospital

Regina, , Canada

Site Status ACTIVE_NOT_RECRUITING

Fundacion Clinica Valle del Lili

Cali, , Colombia

Site Status WITHDRAWN

Fundacion Cardiovascular de Colombia Floridablanca

Floridablanca, , Colombia

Site Status TERMINATED

Odense University Hospital

Odense, , Denmark

Site Status TERMINATED

Universitatsklinik Charite Berlin

Berlin, , Germany

Site Status ACTIVE_NOT_RECRUITING

University KH Bonn

Bonn, , Germany

Site Status TERMINATED

Uniklinik Köln

Cologne, , Germany

Site Status TERMINATED

Uniklinik Köln

Cologne, , Germany

Site Status RECRUITING

Universitaetsklinikum Dusseldorf

Düsseldorf, , Germany

Site Status RECRUITING

Algesiologikum

München, , Germany

Site Status TERMINATED

Sheba Medical Center

Ramat Gan, , Israel

Site Status TERMINATED

Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Site Status TERMINATED

Fondazione Salvatore Maugeri IRCCS

Pavia, , Italy

Site Status RECRUITING

Azienda Ospedaliero Universitaria Pisana

Pisa, , Italy

Site Status TERMINATED

Kobe University Hospital

Kobe, , Japan

Site Status TERMINATED

Hyogo College of Medicine Hospital

Nishinomiya-shi, , Japan

Site Status TERMINATED

Okayama University Hospital

Okayama, , Japan

Site Status TERMINATED

Sakai Hospital Kinki University Faculty of Medicine

Sakaishi, , Japan

Site Status TERMINATED

Ziekenhuis Rijnstate

Velp, , Netherlands

Site Status TERMINATED

Hospital General de Ciudad Real

Ciudad Real, , Spain

Site Status RECRUITING

Hospital La Paz

Madrid, , Spain

Site Status TERMINATED

Hospital La Princesa

Madrid, , Spain

Site Status TERMINATED

Hospital Puerta de Hierro

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario Infanta Elena

Madrid, , Spain

Site Status WITHDRAWN

Clinica Universidad de Navarra

Pamplona, , Spain

Site Status RECRUITING

Hospital Donostia

San Sebastián, , Spain

Site Status ACTIVE_NOT_RECRUITING

H. Marques De Valdecilla

Santander, , Spain

Site Status TERMINATED

Hospital Virgen De La Salud

Toledo, , Spain

Site Status TERMINATED

Hospital General de Valencia

Valencia, , Spain

Site Status RECRUITING

Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status TERMINATED

Ospedale Regionale di Lugano

Viganello, , Switzerland

Site Status TERMINATED

Basildon and Thurrock University Hospitals NHS

Basildon, , United Kingdom

Site Status RECRUITING

Southmead Hospital Bristol

Bristol, , United Kingdom

Site Status RECRUITING

The General Infirmary

Leeds, , United Kingdom

Site Status RECRUITING

Chelsea and Westminster Hospital

London, , United Kingdom

Site Status TERMINATED

St. Bartholomews Hospital

London, , United Kingdom

Site Status ACTIVE_NOT_RECRUITING

Royal National Orthopaedic Hospital

Stanmore, , United Kingdom

Site Status TERMINATED

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Belgium Canada Colombia Denmark Germany Israel Italy Japan Netherlands Spain Sweden Switzerland United Kingdom

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Thanh Hoang, MS

Role: CONTACT

Phone: 855-213-9890

Email: [email protected]

Stephanie Delvaux

Role: CONTACT

Phone: 855-213-9890

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research Manager

Role: primary

Boston Scientific Clinical Research

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Rauck RL, Loudermilk E, Thomson SJ, Paz-Solis JF, Bojrab L, Noles J, Vesper J, Atallah J, Roth D, Hegarty J, Prud'Homme M, Phillips GM, Smith SG, Ibrahim M, Willoughby CD, Obray JB, Gupta M, Paez J, Berg AP, Harrison NJ, Maino P, Mambalam P, McCarty M, Towlerton G, Love-Jones S, Ahmed S, Lee A, Shah B, Goor-Aryeh I, Russo MA, Varela N, Phelps JB, Cid J, Fernandez T, Perez-Hernandez C, Keehn D, Rosenow JM, Haider N, Parrent AG, Lawrence MM, Georgius P, Demartini L, Mendiola A, Mehta V, Thoma R, Israel AF, Carolis G, Bhatia S, Green M, Villarreal A, Crooks MT, Gwinn RP, Pilitsis JG, Sato H, Vega SM, Hillegass MG, Carnes P, Scherer C, Brill S, Yu J, Brennan JJ, Gatzinsky K, Navani A, Snook LT Jr, Bujedo BM, Andres Ares J, Murillo A, Trobridge AT, Assil K, Shah J, McLeod C, Buwembo J, Coster O, Miller N, Sanapati M, Mikhael M, Przkora R, Sukenaga N, Raso LJ, Calodney AK, Caceres Jerez LE, Uchiyama T, Kallewaard JW, Chandler B, Piedimonte F, Candido KD, Weaver TE, Agari T, Holthouse D, Woon R, Patel N, Lechleiter K, Jain R. Long-term safety of spinal cord stimulation systems in a prospective, global registry of patients with chronic pain. Pain Manag. 2023 Feb;13(2):115-127. doi: 10.2217/pmt-2022-0091. Epub 2023 Jan 24.

Reference Type DERIVED
PMID: 36691862 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

90876777

Identifier Type: OTHER

Identifier Source: secondary_id

A7007

Identifier Type: -

Identifier Source: org_study_id