Evaluation of the Efficacy of Somatosensory Rehabilitation of Pain by Vibrotactile Stimulation on Static Mechanical Allodynia

NCT ID: NCT02571010

Last Updated: 2020-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2019-05-02

Brief Summary

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This study aims to demonstrate that somatosensory rehabilitation of pain associated with static mechanical allodynia has superior efficacy over placebo treatment as well as over spontaneous changes.

Detailed Description

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This is a monocenter study. 45 patients will be enrolled in the study, allocated by randomization in 3 arms of 15 patients each.

During the 38 week duration of the study, enrolled patients will be assessed at:

* initial evaluation (first week of the study),
* intermediary evaluation for every week and every modification of intensity of pain,
* final evaluation at 10 weeks,
* follow-up evaluation at 6 months.

Conditions

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Allodynia

Keywords

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static mechanical allodynia somatosensory rehabilitation vibrotactile stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Vibrotactile stimulation

Patients in this arm will have

* treatment by medications and rehabilitation
* treatment by vibrotactile at medical center
* stimulation at home by soft tissue
* non stimulation on allodynia area

Group Type EXPERIMENTAL

Standard Medical treatment

Intervention Type OTHER

Standard treatment with drugs and usual rehabilitation

Vibrotactile stimulation

Intervention Type DEVICE

Rehabilitation by vibrotactile stimulation at medical center

Sham Stimulation with Vibradol device switched off

Patients in this arm will have

* treatment by medications and rehabilitation
* Sham vibrotactile treatment at medical center but with Vibradol device switched off
* abdominal breath exercises at home
* non stimulation on allodynia area

Group Type SHAM_COMPARATOR

Standard Medical treatment

Intervention Type OTHER

Standard treatment with drugs and usual rehabilitation

Sham Stimulation with Vibradol device switched off

Intervention Type DEVICE

Sham Rehabilitation at medical center but with Vibradol device switched off

Standard Medical treatment

Observational group, treated as usually by medications and rehabilitation.

Group Type OTHER

Standard Medical treatment

Intervention Type OTHER

Standard treatment with drugs and usual rehabilitation

Interventions

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Standard Medical treatment

Standard treatment with drugs and usual rehabilitation

Intervention Type OTHER

Vibrotactile stimulation

Rehabilitation by vibrotactile stimulation at medical center

Intervention Type DEVICE

Sham Stimulation with Vibradol device switched off

Sham Rehabilitation at medical center but with Vibradol device switched off

Intervention Type DEVICE

Eligibility Criteria

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Exclusion Criteria

1. Patient with neuralgia (spontaneous pain) with or without allodynia;
2. Patient not able to participate actively to the rehabilitation exercises for physical reason, cognitive reason (ability to understand instructions) or behavioural reason (e.g. addiction...);
3. Patient with complex regional pain syndrome (type I);
4. Patients for whom cares cannot avoid any touch with allodynia area;
5. Patient previously treated by a transcutaneous electrical nerve stimulation (TENS);
6. Prior treatment by somatosensory rehabilitation;
7. Duration of stay in the medical center \< 11 weeks;
8. Patient with cognitive disorder;
9. Allodynia area of the patient presenting with conditions not recommended for vibrotactile stimulation: wound, unhealed nerve suture, recent skin transplantation, fragile organ such as eye.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hôpitaux Universitaires Paris Ile-de-Franc Ouest

OTHER

Sponsor Role collaborator

CRRF La Châtaigneraie

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rania Belmahfoud, MD

Role: STUDY_CHAIR

CRRF La Chataigneraie Convention

Valérie Zingale

Role: STUDY_DIRECTOR

CRRF La Chataigneraie Convention

Locations

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CRRF La Chataigneraie Convention

Paris, Île-de-France Region, France

Site Status

Countries

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France

Other Identifiers

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2014A013 08-39

Identifier Type: REGISTRY

Identifier Source: secondary_id

14RBD-RESISTAL

Identifier Type: -

Identifier Source: org_study_id