Effect of Thoracic Epidural Analgesia for Thoracotomy on the Occurrence of AF
NCT ID: NCT01718717
Last Updated: 2014-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2014-12-31
2017-01-31
Brief Summary
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Detailed Description
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In this study patients who are scheduled for lung resection surgery will undergo the surgery under combined general anesthesia with volatile anesthetics and thoracic epidural anesthesia.
Immediately after surgery the patients will be divided into two groups:
* those who will receive thoracic epidural analgesia for 6 days
* those who will receive thoracic epidural analgesia for 3 days and will then switch to intravenous morphine for another 3 days
All the patients will be monitored daily for arrythmias
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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6 days TEA
Postoperative analgesia for the first six postoperative days with TEA and daily monitoring for arrhythmia
Thoracic Epidural Analgesia (TEA)
3 days TEA and 3 days intravenous morphine
Postoperative analgesia for the first three postoperative days with TEA followed for the next three days with intravenous morphine, and daily monitoring for arrhythmia
TEA followed by Intravenous morphine
Interventions
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Thoracic Epidural Analgesia (TEA)
TEA followed by Intravenous morphine
Eligibility Criteria
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Inclusion Criteria
* pneumonectomy
Exclusion Criteria
* AF (present or in the past
* contraindications for epidural catheter placement
50 Years
ALL
No
Sponsors
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Larissa University Hospital
OTHER
Responsible Party
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Metaxia Bareka
Anesthesiologist
Principal Investigators
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Metaxia Bareka, Medicine
Role: PRINCIPAL_INVESTIGATOR
Larissa University Hospital
Marina Simaioforidou, Medicine
Role: STUDY_CHAIR
Larissa University Hospital
Locations
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Larissa University Hospital
Larissa, Thessally, Greece
Countries
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Central Contacts
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References
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Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000 Dec 16;321(7275):1493. doi: 10.1136/bmj.321.7275.1493.
O'Higgins F, Tuckey JP. Thoracic epidural anaesthesia and analgesia: United Kingdom practice. Acta Anaesthesiol Scand. 2000 Oct;44(9):1087-92. doi: 10.1034/j.1399-6576.2000.440909.x.
Mendola C, Ferrante D, Oldani E, Cammarota G, Cecci G, Vaschetto R, Della Corte F. Thoracic epidural analgesia in post-thoracotomy patients: comparison of three different concentrations of levobupivacaine and sufentanil. Br J Anaesth. 2009 Mar;102(3):418-23. doi: 10.1093/bja/aep004. Epub 2009 Feb 3.
De Cosmo G, Aceto P, Gualtieri E, Congedo E. Analgesia in thoracic surgery: review. Minerva Anestesiol. 2009 Jun;75(6):393-400. Epub 2008 Oct 27.
Wildgaard K, Ravn J, Kehlet H. Chronic post-thoracotomy pain: a critical review of pathogenic mechanisms and strategies for prevention. Eur J Cardiothorac Surg. 2009 Jul;36(1):170-80. doi: 10.1016/j.ejcts.2009.02.005.
Scarci M, Joshi A, Attia R. In patients undergoing thoracic surgery is paravertebral block as effective as epidural analgesia for pain management? Interact Cardiovasc Thorac Surg. 2010 Jan;10(1):92-6. doi: 10.1510/icvts.2009.221127. Epub 2009 Oct 23.
Shrivastava V, Nyawo B, Dunning J, Morritt G. Is there a role for prophylaxis against atrial fibrillation for patients undergoing lung surgery? Interact Cardiovasc Thorac Surg. 2004 Dec;3(4):656-62. doi: 10.1016/j.icvts.2004.08.002.
Oka T, Ozawa Y, Ohkubo Y. Thoracic epidural bupivacaine attenuates supraventricular tachyarrhythmias after pulmonary resection. Anesth Analg. 2001 Aug;93(2):253-9, 1st contents page. doi: 10.1097/00000539-200108000-00003.
Simeoforidou M, Vretzakis G, Bareka M, Chantzi E, Flossos A, Giannoukas A, Tsilimingas N. Thoracic epidural analgesia with levobupivacaine for 6 postoperative days attenuates sympathetic activation after thoracic surgery. J Cardiothorac Vasc Anesth. 2011 Oct;25(5):817-23. doi: 10.1053/j.jvca.2010.08.003. Epub 2010 Oct 13.
Other Identifiers
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TEA and AF
Identifier Type: -
Identifier Source: org_study_id
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