The Correlation Between Renal Injury and Biomarkers in Pediatric Ureteropelvic Junction Obstruction Patients

NCT ID: NCT01711996

Last Updated: 2021-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-08-31

Brief Summary

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Urinary Neutrophil gelatinase associated lipocalin (NGAL) has been recently reported to be related with the degree of hydronephrosis in pediatric ureteropelvic junction obstruction (UPJO) patients. We are trying to analyze whether it is related with the grade of renal injury in UPJO patients.

Detailed Description

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Conditions

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Ureteropelvic Junction Obstruction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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UPJO

0-3 year old hydronephrosis patients without ureter dilatation who undergo pyeloplasty

No interventions assigned to this group

Hydronephrosis

0-3 year old hydronephrosis patients without ureter dilatation who does not meet the indication of pyeloplasty

No interventions assigned to this group

Normal

0-3 year old children without hydronephrosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\<Group 1\>

1. 0-3 year old patients with SFU grade 2 or more hydronephrosis without ureteral dilatation
2. needs pyeloplasty due to differential renal function (DRF)\<40%, decreased DRF by more than 5%, development of urinary tract infection, development of urinary stone, and development of pain related with UPJO \<Group 2\>

1\. 0-3 year old patients with SFU grade 3 or 4 hydronephrosis without ureteral dilatation 2. doesn't meet the above criteria for the indication of pyeloplasty \<Group 3\>

1\. 0-3 year old children without any abnormality of urinary tract

Exclusion Criteria

\<Group 1\>

1. patients with contralateral disease affecting DRF
2. history of previous urinary tract surgery
3. follow up loss before diuretic renogram performed at 6-12 months from operation \<Group 2, 3\>

1\. patients with contralateral disease affecting DRF 2. history of previous urinary tract surgery
Maximum Eligible Age

3 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Urology, Urological Science Institute, Yonsei University, Colleage of Medicine

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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4-2012-0421

Identifier Type: -

Identifier Source: org_study_id

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