Acid Production in Dental Plaque After Exposure to Probiotic Bacteria
NCT ID: NCT01700712
Last Updated: 2012-10-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2010-12-31
2011-10-31
Brief Summary
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Methods. subjects (n=18) were given lozenges with probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for two weeks in a double-blinded, randomized cross-over trial. The concentration of LA in supragingival plaque samples was determined at baseline and after 2 weeks. Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with chair-side methods.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
QUADRUPLE
Study Groups
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L. reuteri (DSM 17938 and ATCC PTA 5289; 1x108 CFU
2 tablets a day for 2 weeks
Probiotic Lactobacilli reuteri
Sugar pill
2 tablets a day for 2 weeks
Placebo
Interventions
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Probiotic Lactobacilli reuteri
Placebo
Eligibility Criteria
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Inclusion Criteria
* no visible open caries lesions or periodontal disease,
Exclusion Criteria
* ingestion of probiotic bacteria within the last two months,
* ingestion of antibiotics within the last two months
18 Years
ALL
Yes
Sponsors
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BioGaia AB
INDUSTRY
Calcin foundation, Denmark
OTHER
University of Copenhagen
OTHER
Responsible Party
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Mette Kirstine Keller
Reasearch Associate
Principal Investigators
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Mette K Keller, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Copenhagen
Locations
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University of Copenhagen
Copenhagen, , Denmark
Countries
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References
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Keller MK, Twetman S. Acid production in dental plaque after exposure to probiotic bacteria. BMC Oral Health. 2012 Oct 24;12:44. doi: 10.1186/1472-6831-12-44.
Other Identifiers
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H-2-2010-112
Identifier Type: -
Identifier Source: org_study_id