The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers

NCT ID: NCT01695109

Last Updated: 2012-09-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-11-30
• Study Completion Date: 2012-03-31

Brief Summary

Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors. A possible mechanism of this effect might be associated with changes in food choices, as suggested by animal studies. It has been shown that functional magnetic resonance imaging (fMRI) of the brain is a valuable tool in obesity research and can be used to study the response of several brain regions to the visual presentation of preferred in comparison to non preferred food items and to non food items The aim of this study is to search for possible effects of liraglutide in comparison to placebo on 1. food choices and 2. changes in brain function as evidenced by fMRI in healthy volunteers.

Findings of this study will help not only to get deeper insight into the mechanism of the anorexic effect of GLP-1 mimetics, but also into the regulation of food choices per se. In the future, it is planned to extend the results of this study in normal weight volunteers to obese diabetic subjects.

Detailed Description

Design: The study is designed as a double blind, placebo controlled, randomized crossover intervention study with two arms (liraglutide first followed by placebo vs. placebo first followed by liraglutide) in 16 healthy male volunteers. fMRI results and food intake are compared between groups baseline vs. end of treatment period and placebo vs. liraglutide.

Intervention: A standard dose of 0.6 mg Liraglutide (oder placebo) will be used, and will be applied subcutaneously each morning for three subsequent days by the study personnel. Study sessions will be performed on the fourth day after placebo/liraglutide interventions.

Study sessions: On study days participants arrive at the trial centre at 8.00 am after a 12h fast. Participants are instructed to eat a light dinner around 8.00 pm the previous day and to spend around 8h resting during the night before the study days. Upon arrival, blood pressure and heart rate is measured and an iv line is started, from which a blood sample is taken from the antecubital vein for blood glucose, insulin and plasma hormone concentrations determination. The occurrence of nausea, vomiting, dizziness or any other adverse events (AE's) is reviewed together with the subject.

Instructions for the fMRI examination are reviewed together with the subject. The subject is advised to leave all ferromagnetic items behind, and baseline hunger/satiety visual analogue scales (VAS) are recorded. Then, the fMRI session with the food items paradigm (together with repeated recordings of hunger/satiety VAS) takes place. Afterwards, another blood sample and hunger/satiety VAS is taken and the subject is allowed to eat ad libitum from a buffet breakfast. Food intake is recorded in detail, including meal choices and calorie intake. After a final hunger/satiety VAS recording and another blood sample subjects are dismissed from the trial centre.

Outcome variables: Main outcome variables are fMRI activity in the brain during the high calorie/low calorie food items paradigm and food intake at the buffet liraglutide vs. placebo at the end of treatment. Secondary outcome parameters are hunger/satiety VAS ratings, total and active plasma ghrelin, peptide YY (PYY), glucose and insulin concentrations.

Conditions

Healthy Human Male Subjects

Keywords

GLP1; obesity; fMRI; ghrelin

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Placebo

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

0.9% NaCl, 0.2 ml

Liraglutide

Group Type: ACTIVE_COMPARATOR

Liraglutide

Intervention Type: DRUG

sc injections of 0.6 mg Liraglutide daily for three continuous days.

Interventions

Liraglutide

sc injections of 0.6 mg Liraglutide daily for three continuous days.

Intervention Type: DRUG

Placebo

0.9% NaCl, 0.2 ml

Intervention Type: DRUG

Other Intervention Names

Victoza; Isotonic saline

Eligibility Criteria

Inclusion Criteria

• Male healthy volunteers
• Age 20-40
• Non-smokers
• Normal body weight (body mass index 19 -25 kg/m2)
• Right handed
• Signed informed consent
• Willingness and ability to comply with the protocol

Exclusion Criteria

• Any history of or current drug abuse including alcohol consumption on a regular basis or binge drinking
• Any history of or current psychiatric disease, including any eating disorder, as assessed by structured interview
• Any history of dieting
• Any condition interfering with fMRI measurements such as ferromagnetic implants or claustrophobia
• Any evidence of relevant renal, liver, thyroid, cardiovascular, or respiratory illness at screening examination
• Any acute illness necessitating medical treatment during the last 3 weeks before study entry, any permanent intake of medication
• Any study participation in the last 3 months
• HIV, hepatitis B or C positive
• Any disease considered relevant for proper performance of the study or risks to the participant, at the discretion of the investigator

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Medical University of Vienna

OTHER

Sponsor Role: lead

Responsible Party

Anton Luger

Head of the Department of Endocrinology & Metabolism

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Anton Luger, MD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Vienna

Locations

Division of Endocrinology and Metabolism, Medical University of Vienna

Vienna, , Austria

Countries

Austria

Other Identifiers

702/2008

Identifier Type: -

Identifier Source: org_study_id