Study Results
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View full resultsBasic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2011-04-30
2016-09-30
Brief Summary
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This will be filled in by people with HHT.
The questionnaire has been designed in paper format.
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Detailed Description
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The Lead Applicant has spent 20 years working on this rare disease, and identified multiple areas where more evidence is required to assist clinicians and patients with this lifelong condition. A particular issue is whether the diet influences HHT or its complications in any way.
In this study, people will fill in two questionnaires, one giving details of their diet, and another details of their nosebleeds. They will also be asked to consider participating in an accessory study arm which includes weighing food for one week and providing a food diary, in addition to having a single set of blood test.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
SUPPORTIVE_CARE
NONE
Study Groups
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Diet and nosebleed questionnaire
Participants will only be required to fill in two paper questionnaires, one on dietary history, and one on nosebleed severity.
Questionnaire on dietary history
Questionnaire on nosebleed severity
Weighed food diary arm
Participants will be required to weigh their food for one week to generate a food dairy, and have a single blood test, in addition to filling in the two paper questionnaires, one on dietary history, and one on nosebleed severity.
Questionnaire on dietary history
Questionnaire on nosebleed severity
One week food diary generated by weighing foods
Blood tests for full blood count, albumin, and indices of nutritional status
Interventions
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Questionnaire on dietary history
Questionnaire on nosebleed severity
One week food diary generated by weighing foods
Blood tests for full blood count, albumin, and indices of nutritional status
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Presence of another major organ disorder that may affect nutritional status, such as inflammatory bowel disease, or celiac disease.
18 Years
ALL
No
Sponsors
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Imperial College London
OTHER
Responsible Party
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Principal Investigators
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Claire L Shovlin, PhD FRCP
Role: PRINCIPAL_INVESTIGATOR
Imperial College London
Locations
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HHTIC London, Hammersmith Hospital, Imperial College Healthcare NHS Trust
London, , United Kingdom
Countries
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References
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Finnamore H, Le Couteur J, Hickson M, Busbridge M, Whelan K, Shovlin CL. Hemorrhage-adjusted iron requirements, hematinics and hepcidin define hereditary hemorrhagic telangiectasia as a model of hemorrhagic iron deficiency. PLoS One. 2013 Oct 16;8(10):e76516. doi: 10.1371/journal.pone.0076516. eCollection 2013.
Finnamore HE, Whelan K, Hickson M, Shovlin CL. Top dietary iron sources in the UK. Br J Gen Pract. 2014 Apr;64(621):172-3. doi: 10.3399/bjgp14X677761. No abstract available.
Chamali B, Finnamore H, Manning R, Laffan MA, Hickson M, Whelan K, Shovlin CL. Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study. Intractable Rare Dis Res. 2016 May;5(2):109-13. doi: 10.5582/irdr.2016.01019.
Finnamore H, Silva BM, Hickson BM, Whelan K, Shovlin CL. 7-day weighed food diaries suggest patients with hereditary hemorrhagic telangiectasia may spontaneously modify their diet to avoid nosebleed precipitants. Orphanet J Rare Dis. 2017 Mar 28;12(1):60. doi: 10.1186/s13023-017-0576-6.
Other Identifiers
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CLS21
Identifier Type: -
Identifier Source: org_study_id
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