Cardiovascular Rehabilitation Early After Stroke Using Feedback-controlled Robotics-assisted Treadmill Exercise

NCT ID: NCT01679600

Last Updated: 2015-08-05

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2014-04-30

Brief Summary

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The propose of this study is to evaluate the feasibility and the clinical efficiency of feedback-controlled robotics-assisted treadmill exercise (RATE) technology for cardiovascular rehabilitation early after stroke. The investigators hypothesize that feedback-controlled RATE might be suitable and effective to improve cardiovascular fitness and functional carryover in non-ambulatory individuals with sub-acute stroke.

Detailed Description

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For detailed info: Stoller O, de Bruin ED, Schuster-Amft C, Schindelholz M, de Bie RA, Hunt KJ. Cardiovascular rehabilitation soon after stroke using feedback-controlled robotics-assisted treadmill exercise: study protocol of a randomized controlled pilot trial. Trials. 2013 Sep 22;14(1):304.

Conditions

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Stroke Cardiovascular Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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FC-RATE

Feedback-controlled robotics-assisted treadmill exercise

Group Type EXPERIMENTAL

Feedback-controlled robotics-assisted treadmill exercise

Intervention Type DEVICE

Progressive cardiovascular exercise using feedback-controlled robotics-assisted treadmill exercise. The first training session is defined to start at 40% of peak work rate (determined from a previous exercise test) to approach 40% of heart rate reserve (Borg scale approximately 11-14). The intensity will then be adjusted on the basis of continuous heart rate data and rating of perceived exertion indications by modulating the target work rate in 5% increments for every subsequent session to reach the target intensity. The target heart rate is set at 40% to 70% of heart rate reserve.

RATE

Robotics-assisted treadmill exercise

Group Type ACTIVE_COMPARATOR

Robotics-assisted treadmill exercise

Intervention Type DEVICE

Conventional robotics-assisted treadmill exercise, where therapists focus on gait quality only.

Interventions

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Feedback-controlled robotics-assisted treadmill exercise

Progressive cardiovascular exercise using feedback-controlled robotics-assisted treadmill exercise. The first training session is defined to start at 40% of peak work rate (determined from a previous exercise test) to approach 40% of heart rate reserve (Borg scale approximately 11-14). The intensity will then be adjusted on the basis of continuous heart rate data and rating of perceived exertion indications by modulating the target work rate in 5% increments for every subsequent session to reach the target intensity. The target heart rate is set at 40% to 70% of heart rate reserve.

Intervention Type DEVICE

Robotics-assisted treadmill exercise

Conventional robotics-assisted treadmill exercise, where therapists focus on gait quality only.

Intervention Type DEVICE

Other Intervention Names

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Lokomat system (Hocoma AG, Volketswil, Switzerland) Lokomat system (Hocoma AG, Volketswil, Switzerland)

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of an initial supratentorial stroke
* ≤20 weeks post stroke at intervention onset
* Age ≥18 years
* Functional Ambulation Category (FAC) ≤3
* Ability to understand the procedures and provide informed consent

Exclusion Criteria

* Contraindications for exercise testing outlined by American College of Sports Medicine (ACSM)
* Contraindications for RATE according to the manufacturer
* Concurrent neurological disease
* Concurrent pulmonary disease
* History of dementia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Maastricht University

OTHER

Sponsor Role collaborator

Reha Rheinfelden

OTHER

Sponsor Role collaborator

Swiss Federal Institute of Technology

OTHER

Sponsor Role collaborator

Bern University of Applied Sciences

OTHER

Sponsor Role lead

Responsible Party

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Oliver Stoller

cand. PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rob A. de Bie, Prof.

Role: STUDY_DIRECTOR

Department of Epidemiology, Maastricht University and Caphri Research School, Maastricht, Netherlands

Kenneth J. Hunt, Prof.

Role: STUDY_DIRECTOR

Institute for Rehabilitation and Performance Technology, Bern University of Applied Sciences, Burgdorf, Switzerland

Eling D. de Bruin, PD Dr.

Role: STUDY_DIRECTOR

Institute of Human Movement Sciences and Sport, ETH Zurich, Switzerland

Thierry Ettlin, Prof.

Role: PRINCIPAL_INVESTIGATOR

Reha Rheinfelden, Rheinfelden, Switzerland

Locations

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Reha Rheinfelden

Rheinfelden, Canton of Aargau, Switzerland

Site Status

Countries

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Switzerland

References

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Stoller O, de Bruin ED, Knols RH, Hunt KJ. Effects of cardiovascular exercise early after stroke: systematic review and meta-analysis. BMC Neurol. 2012 Jun 22;12:45. doi: 10.1186/1471-2377-12-45.

Reference Type BACKGROUND
PMID: 22727172 (View on PubMed)

Stoller O, Schindelholz M, Bichsel L, Schuster C, de Bie RA, de Bruin ED, Hunt KJ. Feedback-controlled robotics-assisted treadmill exercise to assess and influence aerobic capacity early after stroke: a proof-of-concept study. Disabil Rehabil Assist Technol. 2014 Jul;9(4):271-8. doi: 10.3109/17483107.2013.785038. Epub 2013 Apr 18.

Reference Type BACKGROUND
PMID: 23597319 (View on PubMed)

Stoller O, de Bruin ED, Schindelholz M, Schuster C, de Bie RA, Hunt KJ. Evaluation of exercise capacity after severe stroke using robotics-assisted treadmill exercise: a proof-of-concept study. Technol Health Care. 2013;21(2):157-66. doi: 10.3233/THC-130730.

Reference Type BACKGROUND
PMID: 23510976 (View on PubMed)

Stoller O, de Bruin ED, Schuster-Amft C, Schindelholz M, de Bie RA, Hunt KJ. Cardiovascular rehabilitation soon after stroke using feedback-controlled robotics-assisted treadmill exercise: study protocol of a randomised controlled pilot trial. Trials. 2013 Sep 22;14:304. doi: 10.1186/1745-6215-14-304.

Reference Type BACKGROUND
PMID: 24053609 (View on PubMed)

Stoller O, de Bruin ED, Schindelholz M, Schuster-Amft C, de Bie RA, Hunt KJ. Efficacy of Feedback-Controlled Robotics-Assisted Treadmill Exercise to Improve Cardiovascular Fitness Early After Stroke: A Randomized Controlled Pilot Trial. J Neurol Phys Ther. 2015 Jul;39(3):156-65. doi: 10.1097/NPT.0000000000000095.

Reference Type RESULT
PMID: 26050073 (View on PubMed)

Related Links

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http://irpt.ti.bfh.ch

Institute for Rehabilitation and Performance Technology

Other Identifiers

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CardioRobot

Identifier Type: -

Identifier Source: org_study_id

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