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Evaluation of Brain MRI and Clinical Characteristics of Adolescents With Bipolar Disorder and Children of Parents With Bipolar Disorder

NCT ID: NCT01678989

Last Updated: 2012-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2013-06-30

Brief Summary

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Genetic transition is important in the etiology of bipolar disorder (BD). So, evaluation of children of BD parents and diagnosed with and BD children whether or not brain has affected zones. These groups were compared to healthy controls and whether or not the mental health of children is influenced will be evaluated by the clinical investigation.

Detailed Description

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MRI studies in children at risk of BD, our understanding of the neurobiology of BD and abnormalities in the studied regions, regions that predispose to the development of our understanding of PBB will shed light on the etiology of the disorder. In this study, the cranial MRI findings and clinical features in adolescents with bipolar disorder and the same age and sex matched children who have parents with BD and healthy controls were investigated. Since there is few studies that evaluate these three groups, there is a need to increase our knowledge on this issue.

Conditions

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Bipolar Disorder

Keywords

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Bipolar disorder Children Cranial MRI

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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Patient group

Children with BD, (20 children) 12-18 year-old who agreed to participate in the study will be established.

No interventions assigned to this group

Risk group

Twenty healthy children of 12-18 years old who have mothers and/or fathers who previously assessed by an adult psychiatrist and diagnosed as BD according to DSM-IV diagnostic criteria, and who agreed to participate in the study. The age and gender of the groups will be matched.

No interventions assigned to this group

Healthy control group

Twenty participants between the ages of 12-18 who agree to participate in the study and whose family members do not have BD. The age and the gender of the groups will be matched.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children with BD between the ages of 12-18
* Parents with BD who have children between the ages of 12-18
* Healthy children whose parents do not have BD
* Patients who does not have mental or organic disability to answer the questions
* Graduated from primary school

Exclusion Criteria

* Patients who have mental or organic disability to answer the questions
* Patients who have a history of any chronic disease which is likely to affect the central nervous system
* Patients who have a contraindication for any first application for Magnetic Resonance Imaging (MRI)
Minimum Eligible Age

12 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Turkish Psychiatry Association

OTHER

Sponsor Role lead

Responsible Party

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Seher Akbas

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ondokuz Mayis University Medical Faculty Department of Child and Adolescent Psychiatry

Samsun, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Seher Akbas

Role: CONTACT

Phone: 09003623121919

Email: [email protected]

Gökhan Sarisoy

Role: CONTACT

Phone: 09003623121910

Email: [email protected]

Facility Contacts

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Seher Akbas

Role: primary

Other Identifiers

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4946498

Identifier Type: -

Identifier Source: org_study_id