Trial Comparing 19 and 25-gauge EUS-FNA Needles

NCT ID: NCT01677312

Last Updated: 2020-03-17

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-01-31

Brief Summary

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This study compares the 19G and 25G needles for procuring tissue samples from the pancreas during Endoscopic Ultrasound (EUS) procedures.

Detailed Description

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The study compares the median number of passes to establish a definitive diagnosis using the 19G or 25G needles. Also, the ability of both needles to procure a histological core tissue is assessed.

Conditions

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Cancer of Pancreas Pancreatic Neoplasm

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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19G FNA needle

Evaluate median number of passes to diagnosis (Diagnostic accuracy) and ability to procure histological samples using a 19G FNA needle when performing pancreatic biopsy.

Group Type ACTIVE_COMPARATOR

Pancreatic Biopsy

Intervention Type PROCEDURE

A FNA needle will be used to biopsy the pancreatic mass. The rates of diagnostic accuracy (%) will be assessed. Diagnostic accuracy is defined as the proportion of patients in whom a definitive diagnosis can be obtained within a predetermined number of FNA passes.

Histological Samples

Intervention Type PROCEDURE

The proportion of patients (%) in whom a histological tissue can be obtained when performing a biopsy of the pancreas using a specific needle will be assessed.

25G FNA needle

Evaluate median number of passes to diagnosis (Diagnostic accuracy) and ability to procure histological samples using a 25G FNA needle when performing pancreatic biopsy.

Group Type ACTIVE_COMPARATOR

Pancreatic Biopsy

Intervention Type PROCEDURE

A FNA needle will be used to biopsy the pancreatic mass. The rates of diagnostic accuracy (%) will be assessed. Diagnostic accuracy is defined as the proportion of patients in whom a definitive diagnosis can be obtained within a predetermined number of FNA passes.

Histological Samples

Intervention Type PROCEDURE

The proportion of patients (%) in whom a histological tissue can be obtained when performing a biopsy of the pancreas using a specific needle will be assessed.

Interventions

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Pancreatic Biopsy

A FNA needle will be used to biopsy the pancreatic mass. The rates of diagnostic accuracy (%) will be assessed. Diagnostic accuracy is defined as the proportion of patients in whom a definitive diagnosis can be obtained within a predetermined number of FNA passes.

Intervention Type PROCEDURE

Histological Samples

The proportion of patients (%) in whom a histological tissue can be obtained when performing a biopsy of the pancreas using a specific needle will be assessed.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

(1) Patients with solid pancreatic mass lesions.

Exclusion Criteria

1. Age \< 19 years
2. Unable to safely undergo EUS for any reason
3. Coagulopathy (INR \> 1.6, Prothrombin Time \> 18secs, Thrombocytopenia \< 80,000 cells/ml)
4. Unable to consent
5. Non-English speaking patients
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Alabama at Birmingham

OTHER

Sponsor Role collaborator

AdventHealth

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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shyam varadarajulu, MD

Role: PRINCIPAL_INVESTIGATOR

Florida Hospital Center for Interventional Endoscopy

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Florida Hospital

Orlando, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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356077

Identifier Type: -

Identifier Source: org_study_id

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