Effect of Citrus Bioflavonoids/Vitamin E in Conjunction With Fish Oil Supplementation

NCT ID: NCT01671254

Last Updated: 2018-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2012-12-31

Brief Summary

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The purpose of this 8-week intervention trial is to investigate the effect of a dietary supplement (containing citrus bioflavonoids and vitamin E) plus fish oil supplementation in healthy hyperlipidemic subjects

Detailed Description

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Conditions

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Hyperlipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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FishOil + placebo

Subjects in this arm receive fish oil (EPA/DHA Extra Strength) and placebo capsule

Group Type ACTIVE_COMPARATOR

FishOil

Intervention Type DIETARY_SUPPLEMENT

placebo

Intervention Type DIETARY_SUPPLEMENT

FishOil + CBE75

Subjects in this arm receive fish oil (EPA/DHA Extra Strength) and citrus bioflavonoids+vitamin E (CBE)(75 mg/capsule/day)

Group Type EXPERIMENTAL

FishOil

Intervention Type DIETARY_SUPPLEMENT

CBE75

Intervention Type DIETARY_SUPPLEMENT

FishOil + CBE150

Subjects in this arm receive fish oil (EPA/DHA Extra Strength) and CBE (150 mg/capsule/day)

Group Type EXPERIMENTAL

FishOil

Intervention Type DIETARY_SUPPLEMENT

CBE150

Intervention Type DIETARY_SUPPLEMENT

Interventions

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FishOil

Intervention Type DIETARY_SUPPLEMENT

CBE75

Intervention Type DIETARY_SUPPLEMENT

CBE150

Intervention Type DIETARY_SUPPLEMENT

placebo

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* men and women ≥ 18 and ≤ 72 years old
* generally healthy
* BMI \> 18 and \< 38
* LDL cholesterol ≥ 130 mg/dl and \< 270 mg/dl
* triglycerides ≥ 150 mg/dl and \< 400 mg/dl
* ability to understand and the willingness to sign a written informed consent

Exclusion Criteria

* use of nutritional supplements and medical foods for dyslipidemia within 30 days prior to the study
* use of omega-3 fatty acid dietary supplements within 30 days prior to the study
* use of prescription HMG-CoA reductase inhibitors, bile acid sequestrants, fibrates, cholesterol absorption blocking agents, or niacin
* use of prescription medications and/or nonprescription medications for acute and semi-acute medical conditions
* history of cardiovascular disease, type i diabetes, autoimmune disease, liver or kidney disease, malignancy, and serious mental illness.
* known infection with HIB, TB, hepatitis B or hepatitis C
* history of allergy or intolerance to study products
* smoking, use of nicotine-containing products, or use of drugs of abuse 30 days prior to the study
* history of regular intake of \> 14 alcoholic drinks per week for females and \> 21 drinks per week for males
Minimum Eligible Age

18 Years

Maximum Eligible Age

72 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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MetaProteomics LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joseph J Lamb, MD

Role: PRINCIPAL_INVESTIGATOR

MetaProteomics / Metagenics / FMRC

Locations

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Functional Medicine Research Center

Gig Harbor, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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POT2-FMR-CT

Identifier Type: -

Identifier Source: org_study_id

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