The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-11-30

Study Completion Date

2008-12-31

Brief Summary

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Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.

Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia

Detailed Description

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Conditions

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Neutropenia

Keywords

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neutropenia multiplex PCR infection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Bone marrow transplant unit patients

hospitalized patients in the bone marrow transplant unit for an autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients aged ≥18 years
* autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy performed

Exclusion Criteria

* No blood samples were taken

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Andrej Trampuz

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrej Trampuz, MD

Role: STUDY_DIRECTOR

University Hospital Lausanne, Switzerland

Christina Orasch, MD

Role: PRINCIPAL_INVESTIGATOR