DetectAB - Detecting Antibiotics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

17 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-01

Study Completion Date

2019-10-31

Brief Summary

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The secretion of different kinds of antibiotic drugs in sweat is investigated. The concentration and pharmacodynamics of antibiotic drugs in sweat and blood will be compared.

Detailed Description

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Conditions

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Antibiotic Drug Concentration in Sweat

Keywords

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antibiotic drug monitoring in sweat

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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analysis of last resort antibiotic drug (Flucloxacillin, Imipenem, Vancomycin or Cefepim) in sweat and blood

blood draw (4.7 ml EDTA) and sweat sample taken (Macroduct Sweat Collecting System)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adult patients
* Ability to understand the purpose of the study, provide signed and dated informed consent and qualify for therapeutic drug monitoring
* In-patients receiving intravenous therapy with last resort antibiotics Cefepim, Floxapen, Imipenem or Vancomycin for at least 24 hours
* Glomerular Filtration Rate \>/= 50 ml/Min

Exclusion Criteria

* Glomerular Filtration Rate \< 50 ml/Min

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jens Eckstein, PD Dr. med

Role: PRINCIPAL_INVESTIGATOR

Chief Clinical Medical Office

Locations

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University Hospital Basel

Basel, , Switzerland

Site Status

Countries

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Switzerland

References

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Brasier N, Widmer A, Osthoff M, Mutke M, De Ieso F, Brasier-Lutz P, Wolfe L, Aithal V, Broeckling CD, Prenni J, Eckstein J. Non-invasive Drug Monitoring of beta-Lactam Antibiotics Using Sweat Analysis-A Pilot Study. Front Med (Lausanne). 2020 Aug 25;7:476. doi: 10.3389/fmed.2020.00476. eCollection 2020.

Reference Type DERIVED

PMID: 32984371 (View on PubMed)

Other Identifiers

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2018-01155; me18Eckstein

Identifier Type: -

Identifier Source: org_study_id