Effect of Intravitreal Anti-VEGF on Retinal Vessels Diameter

NCT ID: NCT01626339

Last Updated: 2012-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Brief Summary

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Patients who will be scheduled for intravitreal injection of Ranibizumab or Bevacizumab will be recruited in this prospective self-controlled trial. Fundus photography will carried out at baseline immediately before injection and at 3, 7 days and 30 days after the first injection. Using image analysis software, measurements summarized as the central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE).

Null Hypothesis: There is no significant difference between arteriolar/venular diameter before and after injection of intravitreal ranibizumab/bevacizumab in the treated and untreated eye

Detailed Description

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Conditions

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Age Related Macular Degeneration

Interventions

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Intravitreal Ranibizumab

Intervention Type DRUG

Intravitreal bevacizumab

Intervention Type DRUG

Other Intervention Names

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Lucentis Avastin

Eligibility Criteria

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Inclusion Criteria

• Patients who wish and need bevacizumab or ranibizumab treatment for underlying disease

Exclusion Criteria

* History of previous systemic or ocular Anti-VEGF therapy
* History of previous intravitreal injection with any drug
* Intraocular pressure ≥ 22
* Glaucoma
* History or presence of thromboembolic events
* Un-controlled blood pressure
* Blood donation during the previous 3 weeks
* Relevant media opacity of the lens
Minimum Eligible Age

20 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Malaya

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Malaya Medical Center

Kuala Lumpur, Kuala Lumpur, Malaysia

Site Status RECRUITING

Countries

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Malaysia

Central Contacts

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Mohammadreza Peyman, MD

Role: CONTACT

0060173387260 ext. 1

Visvaraja Subrayan, Prof

Role: CONTACT

Facility Contacts

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Mohammadreza Peyman, MD

Role: primary

0060173387260

Other Identifiers

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PPUM/MDU/300/04/03

Identifier Type: -

Identifier Source: org_study_id

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