Understanding and Diagnosing Allergic Disease in Twins

NCT ID: NCT01613885

Last Updated: 2021-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

340 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Study Completion Date

2019-10-31

Brief Summary

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The purpose of this study is to gain better understanding of how the immune system works in twins with and without allergic disease. Healthy volunteers are not specifically targeted. Healthy non-allergic study participants may be found through the course of evaluation for the presence of allergies.

Detailed Description

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The purpose of this study is to study the genetic control and gain better understanding of how the immune system works in twins with and without allergic disease. Although healthy volunteers are not specifically targeted, they might be identified when non-allergic study participants are found through the course of evaluation for the presence of allergies.

Conditions

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Allergies

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Twins

Twins that are ages 0 to 80 years, with or without allergy disease.

No Intervention

Intervention Type OTHER

This study does not involve any intervention other than obtaining blood, nasal/cheek/throat/skin swabs, saliva, sputum, urine, and stool samples, breathing and skin tests.

Interventions

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No Intervention

This study does not involve any intervention other than obtaining blood, nasal/cheek/throat/skin swabs, saliva, sputum, urine, and stool samples, breathing and skin tests.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Twin participants ages 0 to 80 years who are with or without allergy disease.

Exclusion Criteria

* Patients with special risks attendant to venipuncture will be excluded.
Minimum Eligible Age

0 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Kari Christine Nadeau, MD, PhD

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kari Nadeau, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Sean N Parker Center for Allergy and Asthma Research at Stanford

Stanford, California, United States

Site Status

Stanford University School of Medicine

Stanford, California, United States

Site Status

Countries

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United States

References

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Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021 Jan 19;131(2):e141935. doi: 10.1172/JCI141935.

Reference Type DERIVED
PMID: 33463536 (View on PubMed)

Other Identifiers

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SU-10042011-8546

Identifier Type: -

Identifier Source: org_study_id

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