Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

NCT ID: NCT01598259

Last Updated: 2016-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2016-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The specific aims of this investigation in children during burn rehabilitation include 1.) to determine the efficacy of melatonin intervention on improving sleep-related outcomes 2.) investigate the hypothesis that sleep inadequacy is associated with cognitive deficits and 3.) develop a new methodology specific for burn patients that accurately screens for the presence of intrinsic dyssomnia.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Burns

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

melatonin

Subjects will receive melatonin

Group Type EXPERIMENTAL

Melatonin

Intervention Type DRUG

po 1 hour before bedtime

placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type OTHER

po, 1 hour before bed

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Melatonin

po 1 hour before bedtime

Intervention Type DRUG

placebo

po, 1 hour before bed

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* History of burn injury
* Scheduled for an elective surgical procedure
* 5 - 22 years of age, inclusive

Exclusion Criteria

* History of anoxic brain injury
* History of head injury within the last year
* Pre-existing seizure disorder
* Pre-existing neurological disorder
* Pre-existing blindness
* Known hypersensitivity to melatonin
* Anticoagulant use or aspirin therapy
* Antihypertensive medication use
* Diabetes mellitus or other endocrine disorders
* Autoimmune disorders
* Schizophrenia
* Inability to access internet
* Intellectual disability or inability to follow directions
Minimum Eligible Age

5 Years

Maximum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Shriners Hospitals for Children

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Michele Gottschlich

Research Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Shriners Hospital for Children

Cincinnati, Ohio, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2012-1613

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Pilot Study of Melatonin and Epilepsy
NCT00965575 COMPLETED PHASE2
Melatonin fOr CHronic bAck Pain (The MOCHA Trial)
NCT06476392 ACTIVE_NOT_RECRUITING PHASE3
Melatonin Adolescent Research Study
NCT04588233 RECRUITING NA
Melatonin for Sleep in MS
NCT04035889 COMPLETED NA