Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia
NCT ID: NCT01087359
Last Updated: 2011-06-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
12 participants
INTERVENTIONAL
2010-06-30
2011-02-28
Brief Summary
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* day 1: On day time administration of LPS.
* day 2: On night time administration of LPS.
* day 3: On day time administration of LPS + Placebo.
* day 4: On day time administration of LPS + melatonin.
* day 5: On night time administration of LPS + placebo.
* day 6: On night time administration og LPS + melatonin.
Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
DOUBLE
Study Groups
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LPS + melatonin night
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
LPS + placebo night
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
LPS + melatonin day
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
LPS + placebo day
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
LPS night
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
LPS day
Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
Interventions
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Melatonin
100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo
Eligibility Criteria
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Inclusion Criteria
* Age 18-49 year.
* Healthy
* No sleepiness disorders.
* No medication
* ASA I
Exclusion Criteria
* Women
* Smoking.
* Alcohol abuse.
18 Years
40 Years
MALE
Yes
Sponsors
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Herlev Hospital
OTHER
Responsible Party
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MA
Locations
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Herlev Hospital
Herlev, , Denmark
Countries
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Other Identifiers
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H-2-2010-010
Identifier Type: -
Identifier Source: org_study_id
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