Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
796 participants
INTERVENTIONAL
2010-06-30
2013-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Cyclosporine A
Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
Cyclosporine A
Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
cardio-pulmonary resuscitation
usual care of cardiac arrest
Control
usual care of cardiac arrest
cardio-pulmonary resuscitation
usual care of cardiac arrest
Interventions
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Cyclosporine A
Single intravenous bolus of cyclosporine A (2.5 mg/kg) at the onset of resuscitation
cardio-pulmonary resuscitation
usual care of cardiac arrest
Eligibility Criteria
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Inclusion Criteria
* Non shockable cardiac rhythm
Exclusion Criteria
* Evidence of pregnancy
* Duration of no flow more than 30 minutes
* Rapidly fatal underlying disease
* Allergy to cyclosporin A
18 Years
80 Years
ALL
No
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Principal Investigators
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Laurent ARGAUD, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Groupement Hospitalier Edouard Herriot,69437 Lyon Cedex 03
Locations
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Medical intensive care unit, Edouard Herriot Hospital
Lyon, , France
Countries
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References
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Argaud L, Cour M, Dubien PY, Giraud F, Jossan C, Riche B, Hernu R, Darmon M, Poncelin Y, Tchenio X, Quenot JP, Freysz M, Kamga C, Beuret P, Usseglio P, Badet M, Anette B, Chaulier K, Alasan E, Sadoune S, Bobbia X, Zeni F, Gueugniaud PY, Robert D, Roy P, Ovize M; CYRUS Study Group. Effect of Cyclosporine in Nonshockable Out-of-Hospital Cardiac Arrest: The CYRUS Randomized Clinical Trial. JAMA Cardiol. 2016 Aug 1;1(5):557-65. doi: 10.1001/jamacardio.2016.1701.
Madelaine T, Cour M, Roy P, Vivien B, Charpentier J, Dumas F, Deye N, Bonnefoy E, Gueugniaud PY, Coste J, Cariou A, Argaud L. Prediction of Brain Death After Out-of-Hospital Cardiac Arrest: Development and Validation of the Brain Death After Cardiac Arrest Score. Chest. 2021 Jul;160(1):139-147. doi: 10.1016/j.chest.2021.01.056. Epub 2021 Jun 8.
Other Identifiers
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2009-015725-37
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
2009.571
Identifier Type: -
Identifier Source: org_study_id
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