Acute Effects of Exercise in Women With Fibromyalgia (FM)

NCT ID: NCT01592916

Last Updated: 2018-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

55 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-05-10

Study Completion Date

2012-11-23

Brief Summary

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The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM.

Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Fibromyalgia

Women with fibromyalgia, aged 20-50 years

No interventions assigned to this group

Healthy controls

Women without severe disease, aged 20-50 years

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of fibromyalgia
* age 20-50 years

Exclusion Criteria

* heart disease
* neurological disease
* severe osteoarthritis
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role collaborator

The Swedish Research Council

OTHER_GOV

Sponsor Role collaborator

Göteborg University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kaisa Mannerkorpi, Assoc prof

Role: PRINCIPAL_INVESTIGATOR

Göteborg University

Locations

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Sahlgrenska University Hospital, Dept of Physical Therapy

Gothenburg, , Sweden

Site Status

Countries

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Sweden

References

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Mannerkorpi K, Landin-Wilhelmsen K, Larsson A, Cider A, Arodell O, Bjersing JL. Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia. BMC Musculoskelet Disord. 2017 Jan 25;18(1):37. doi: 10.1186/s12891-017-1402-y.

Reference Type RESULT
PMID: 28122522 (View on PubMed)

Other Identifiers

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GU-143-12

Identifier Type: -

Identifier Source: org_study_id

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