Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide

NCT ID: NCT01576627

Last Updated: 2013-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2012-11-30

Brief Summary

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The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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zinc citrate

Group Type EXPERIMENTAL

zinc citrate

Intervention Type DIETARY_SUPPLEMENT

10 mg of zinc as either zinc citrate

zinc gluconate

Group Type ACTIVE_COMPARATOR

Zinc Gluconate

Intervention Type DIETARY_SUPPLEMENT

10 mg of zinc as either zinc gluconate

zinc oxide

Group Type ACTIVE_COMPARATOR

Zinc oxide

Intervention Type DIETARY_SUPPLEMENT

10 mg of zinc as either zinc oxide

Interventions

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zinc citrate

10 mg of zinc as either zinc citrate

Intervention Type DIETARY_SUPPLEMENT

Zinc Gluconate

10 mg of zinc as either zinc gluconate

Intervention Type DIETARY_SUPPLEMENT

Zinc oxide

10 mg of zinc as either zinc oxide

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male or female of 18 to 45 years old
* Body Mass Index in the range of 19 to 25
* No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria

* Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
* Long-term medication during the whole study (except for contraceptives)
* Vegans
* Pregnancy
* Lactation
* Intention to become pregnant during the course of the study
* Lack of safe contraception
* Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration
* Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role collaborator

Prof. Michael B. Zimmermann

OTHER

Sponsor Role lead

Responsible Party

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Prof. Michael B. Zimmermann

Prof

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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ETH Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Wegmuller R, Tay F, Zeder C, Brnic M, Hurrell RF. Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide. J Nutr. 2014 Feb;144(2):132-6. doi: 10.3945/jn.113.181487. Epub 2013 Nov 20.

Reference Type DERIVED
PMID: 24259556 (View on PubMed)

Other Identifiers

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HNL/CTC11-12

Identifier Type: -

Identifier Source: org_study_id

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