Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery

NCT ID: NCT01550159

Last Updated: 2012-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

88 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2013-04-30

Brief Summary

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This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.

Detailed Description

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The systemic inflammatory response after cardiac surgery may cause damage to the central nervous system and elevated markers of brain injury in peripheral blood. This event may be potentially related to the development of postoperative cognitive dysfunction (POCD), with incidences varying from 20 to 83%.

Conditions

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Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients underwent for coronary artery bypass graft surgery

Exclusion Criteria

* History of brain disease or dementia, other psychiatric disorders that affect cognition
* Lack of proficiency in Portuguese language
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role collaborator

Maria José Carvalho Carmona

OTHER

Sponsor Role lead

Responsible Party

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Maria José Carvalho Carmona

Study of Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Maria JC Carmona, MD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo Medical School

Locations

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General Hospital of the University od São Paulo Medical School

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Maria JC Carmona, M.D.

Role: CONTACT

55-11-3069-6335

Fernando CP Silva

Role: CONTACT

55-11-3069-6335

Facility Contacts

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Maria JC Carmona, M.D.

Role: primary

55-11-3069-6335

References

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Silva FP, Schmidt AP, Valentin LS, Pinto KO, Zeferino SP, Oses JP, Wiener CD, Otsuki DA, Tort AB, Portela LV, Souza DO, Auler JO Jr, Carmona MJ. S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study. Eur J Anaesthesiol. 2016 Sep;33(9):681-9. doi: 10.1097/EJA.0000000000000450.

Reference Type DERIVED
PMID: 27433840 (View on PubMed)

Other Identifiers

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1081/04

Identifier Type: -

Identifier Source: org_study_id

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