Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE

NCT ID: NCT01546909

Last Updated: 2017-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

278 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2012-12-31

Brief Summary

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PRIMARY OBJECTIVES

* To describe in 11 to 13-year-old children previously vaccinated with either REVAXIS or DT Polio at 6 years of age the antibody persistence against diphtheria, tetanus, and poliovirus types 1, 2 and 3
* To describe one month after a booster dose of TETRAVAC-ACELLULAIRE the immune responses against diphtheria, tetanus, and poliovirus types 1, 2 and 3

SECONDARY OBJECTIVES

* To describe other parameters of the antibody persistence against diphtheria, tetanus and poliomyelitis antigens
* To describe other parameters of the immune responses to diphtheria, tetanus and poliomyelitis antigens one month after a booster dose of TETRAVAC-ACELLULAIRE
* To describe the safety profile of a booster dose of TETRAVAC-ACELLULAIRE

Detailed Description

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Conditions

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Diphtheria Tetanus Poliomyelitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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TETRAVAC-ACELLULAIRE

Group Type EXPERIMENTAL

Diphtheria, tetanus, polio and pertussis vaccination

Intervention Type BIOLOGICAL

1 dose of TETRAVAC-ACELLULAIRE (0.5 mL) at Day 0

Interventions

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Diphtheria, tetanus, polio and pertussis vaccination

1 dose of TETRAVAC-ACELLULAIRE (0.5 mL) at Day 0

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Healthy child 11 to 13 years of age previously vaccinated in Study F05-TdI-301

Exclusion Criteria

* Immunization against diphtheria, tetanus, pertussis and/or poliomyelitis beyond Study F05-TdI-301
* Previous clinical or bacteriological diagnosis of diphtheria, tetanus, pertussis or poliomyelitis
* Known or suspected immune dysfunction
* Receipt of medications / vaccination that may interfere with study assessments
* Known true hypersensitivity to any of the vaccine components or to a vaccine containing the same substances
* Known personal history of encephalopathy, seizure disorder or progressive, evolving or unstable neurological condition
* Thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injection
* Any medical condition that might interfere with the evaluation of the study objectives
* Febrile illness
Minimum Eligible Age

11 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sanofi Pasteur, a Sanofi Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Sanofi Pasteur, a Sanofi Company

Locations

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SPMSD Investigational Site 120

Angers, , France

Site Status

SPMSD Investigational Site 103

Arras, , France

Site Status

SPMSD Investigational Site 155

Asnières, , France

Site Status

SPMSD Investigational Site 125

Bersée, , France

Site Status

SPMSD Investigational Site 121

Besançon, , France

Site Status

SPMSD Investigational Site 141

Besançon, , France

Site Status

SPMSD Investigational Site 124

Blois, , France

Site Status

SPMSD Investigational Site 161

Blois, , France

Site Status

SPMSD Investigational Site 194

Boulogne-Billancourt, , France

Site Status

SPMSD Investigational Site 148

Brest, , France

Site Status

SPMSD Investigational Site 117

Caen, , France

Site Status

SPMSD Investigational Site 147

Caen, , France

Site Status

SPMSD Investigational Site 163

Champdeniers, , France

Site Status

SPMSD Investigational Site 135

Châlons-en-Champagne, , France

Site Status

SPMSD Investigational Site 145

Chigny-les-Roses, , France

Site Status

SPMSD Investigational Site 157

Cholet, , France

Site Status

SPMSD Investigational Site 101

Clamart, , France

Site Status

SPMSD Investigational Site 160

Collombey Les Belles, , France

Site Status

SPMSD Investigational Site 162

Collombey Les Belles, , France

Site Status

SPMSD Investigational Site 139

Dax, , France

Site Status

SPMSD Investigational Site 193

Draguignan, , France

Site Status

SPMSD Investigational Site 106

Essey-lès-Nancy, , France

Site Status

SPMSD Investigational Site 123

Essey-lès-Nancy, , France

Site Status

SPMSD Investigational Site 164

Essey-lès-Nancy, , France

Site Status

SPMSD Investigational Site 136

Floirac, , France

Site Status

SPMSD Investigational Site 114

Frouard, , France

Site Status

SPMSD Investigational Site 150

Haguenau, , France

Site Status

SPMSD Investigational Site 113

Illkirch-Graffenstaden, , France

Site Status

SPMSD Investigational Site 197

Le Havre, , France

Site Status

SPMSD Investigational Site 198

Le Havre, , France

Site Status

SPMSD Investigational Site 107

Lingolsheim, , France

Site Status

SPMSD Investigational Site 115

Louverné, , France

Site Status

SPMSD Investigational Site 140

Manduel, , France

Site Status

SPMSD Investigational Site 116

Maromme, , France

Site Status

SPMSD Investigational Site 153

Marseille, , France

Site Status

SPMSD Investigational Site 134

Montpellier, , France

Site Status

SPMSD Investigational Site 129

Nogent-sur-Marne, , France

Site Status

SPMSD Investigational Site 133

Ostwald, , France

Site Status

SPMSD Investigational Site 128

Poitiers, , France

Site Status

SPMSD Investigational Site 130

Pont-à-Mousson, , France

Site Status

SPMSD Investigational Site 151

Quimper, , France

Site Status

SPMSD Investigational Site 102

Rouen, , France

Site Status

SPMSD Investigational Site 110

Rouen, , France

Site Status

SPMSD Investigational Site 199

Rouen, , France

Site Status

SPMSD Investigational Site 152

Saint-Ouen, , France

Site Status

Countries

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France

Other Identifiers

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RVX01C

Identifier Type: -

Identifier Source: org_study_id

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