Pharmacokinetic Study of Aerosolized Colimycin in Cystic Fibrosis

NCT ID: NCT01537614

Last Updated: 2016-10-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Pharmacokinetics of colimycin will be assessed during 12 hours after administration of 2M UI colimycin either as an aerosol or after IV injection, the administration being separated by 5 to 10 days intervals

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cystic Fibrosis

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

COLIMYCINE injectable

Group Type EXPERIMENTAL

COLIMYCINE injectable

Intervention Type DRUG

2 MILLIONS UI

COLIMYCINE inhalation

Group Type EXPERIMENTAL

COLIMYCINE inhalation

Intervention Type DRUG

2 MILLION UI

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

COLIMYCINE inhalation

2 MILLION UI

Intervention Type DRUG

COLIMYCINE injectable

2 MILLIONS UI

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males and females, adults.
* Suffering from stable cystic fibrosis
* Colonized by P. aeruginosa
* Having given informed consent.
* Able to follow the protocol
* Having a social insurance

Exclusion Criteria

* Renal insufficiency
* Allergy to colistin or polymixins
* Myasthenia
* Recent severe hemoptysis
* Liver cirrhosis and hepatic insufficiency
* Hypoalbuminemia
* Colonization by Burkholderia cepaea or Stenotrophomonas maltophilin
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Poitiers University Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Poitiers University Hospital

Poitiers, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

COLI-VLM

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

SD Cystic Fibrosis Study
NCT00605761 COMPLETED PHASE1
First Study of Oral Cysteamine in Cystic Fibrosis
NCT02212431 COMPLETED PHASE1/PHASE2
Airway Microbiome of Cystic Fibrosis Patients
NCT06057558 ACTIVE_NOT_RECRUITING NA