Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia
NCT ID: NCT01521650
Last Updated: 2021-03-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
42 participants
INTERVENTIONAL
2012-01-31
2020-07-31
Brief Summary
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Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems.
For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures.
Randomisation
* No prophylaxis
* Preparation with a probiotic suspension before intubation.
Cultures
* oropharynx
* before treatment
* after intubation
* before extubation
* day 1 postoperatively
* tracheal secretions
* after intubation
* before extubation
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Probiotics
Patients will gurgle and swallow a mixture of probiotic bacteria
Probiotics
Patients will gurgle and swallow a mixture of probiotic bacteria
Control
No intervention. What has been the standard procedure so far
No interventions assigned to this group
Interventions
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Probiotics
Patients will gurgle and swallow a mixture of probiotic bacteria
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Planned interventions
* Anaesthesia \> 4 hours and requiring intubation
Exclusion Criteria
* Current infections in the airways
* Known immuno deficiences
* Emergency cases
18 Years
ALL
No
Sponsors
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Lund University
OTHER
Region Skane
OTHER
Responsible Party
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Bengt Klarin
MD Consultant
Principal Investigators
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Bengt klarin, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Lund University
Locations
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Lund University Hospital
Lund, , Sweden
Countries
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References
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Stjernquist-Desatnik A, Warfving H, Johansson ML. Persistence of Lactobacillus plantarum DSM 9843 on human tonsillar surface after oral administration in fermented oatmeal gruel. A pilot study. Acta Otolaryngol Suppl. 2000;543:215-9. doi: 10.1080/000164800454422.
Klarin B, Molin G, Jeppsson B, Larsson A. Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study. Crit Care. 2008;12(6):R136. doi: 10.1186/cc7109. Epub 2008 Nov 6.
Other Identifiers
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ProAnest
Identifier Type: -
Identifier Source: org_study_id
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