A Safety Study of 3 Different Bowel Cleansing Preparations

NCT ID: NCT01501513

Last Updated: 2024-01-17

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

541 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2013-03-04

Brief Summary

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The objective of this study is to compare the safety, tolerance and efficacy of BLI800 (approved and investigational regimens) to an approved control preparation as bowel preparations prior to colonoscopy in adult patients, particularly including the elderly and those with renal and/or hepatic impairment.

Detailed Description

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Conditions

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Colonoscopy Bowel Preparation Endoscopy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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BLI800 approved preparation regimen

BLI800 approved preparation regimen

Group Type EXPERIMENTAL

BLI800 approved preparation regimen

Intervention Type DRUG

solution for oral administration prior to colonoscopy

BLI800 investigational preparation regimen

BLI800 investigational preparation regimen

Group Type EXPERIMENTAL

BLI800 investigational preparation regimen

Intervention Type DRUG

solution for oral administration prior to colonoscopy

PEG-3350 based bowel preparation

PEG-3350 based bowel preparation

Group Type ACTIVE_COMPARATOR

PEG-3350 based bowel preparation

Intervention Type DRUG

solution for oral administration prior to colonoscopy

Interventions

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PEG-3350 based bowel preparation

solution for oral administration prior to colonoscopy

Intervention Type DRUG

BLI800 approved preparation regimen

solution for oral administration prior to colonoscopy

Intervention Type DRUG

BLI800 investigational preparation regimen

solution for oral administration prior to colonoscopy

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female outpatients who are undergoing colonoscopy for a routinely accepted indication.
* At least 18 years of age
* If female, and of child-bearing potential, is using an acceptable form of birth control
* Negative urine pregnancy test at screening, if applicable
* In the Investigator's judgment, subject is mentally competent to provide informed consent to participate in the study

Exclusion Criteria

* Subjects with known or suspected ileus, severe ulcerative colitis, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis or megacolon.
* Subjects who had previous significant gastrointestinal surgeries.
* Subjects who have uncontrolled clinically significant pre-existing electrolyte disturbances.
* Subjects with severe liver or renal insufficiency.
* Subjects with a history of congestive heart failure or other clinically significant cardiac abnormality.
* Subjects with impaired consciousness that predisposes them to pulmonary aspiration.
* Subjects undergoing colonoscopy for foreign body removal and decompression.
* Subjects who are pregnant or lactating, or intending to become pregnant during the study.
* Subjects of childbearing potential who refuse a pregnancy test.
* Subjects allergic to any preparation components
* Subjects who, in the opinion of the Investigator, should not be included in the study for any reason, including inability to follow study procedures.
* Subjects who have participated in an investigational surgical, drug, or device study within the past 30 days.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Braintree Laboratories

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of South Alabama

Mobile, Alabama, United States

Site Status

Advanced Clinical Research Institute

Anaheim, California, United States

Site Status

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Site Status

Borland-Groover Clinic

Jacksonville, Florida, United States

Site Status

Miami Research Associates

South Miami, Florida, United States

Site Status

Indiana University

Indianapolis, Indiana, United States

Site Status

Delta Research Partners

Monroe, Louisiana, United States

Site Status

Commonwealth Clinical Studies

Brockton, Massachusetts, United States

Site Status

Gastrointestinal Associates

Jackson, Mississippi, United States

Site Status

Asheville Gastroenterology Associates

Asheville, North Carolina, United States

Site Status

Carolina Digestive Health Associates

Charlotte, North Carolina, United States

Site Status

Wake Research Associates

Raleigh, North Carolina, United States

Site Status

Consultants for Clinical Research

Cincinnati, Ohio, United States

Site Status

Northwest Gastroenterology

Portland, Oregon, United States

Site Status

ClinSearch

Chattanooga, Tennessee, United States

Site Status

Franklin Gastroenterology

Franklin, Tennessee, United States

Site Status

Charlottesville Medical Research

Charlottesville, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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BLI800-440

Identifier Type: -

Identifier Source: org_study_id

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