Safety and Efficacy of OsmoPrep® Tablets Versus HalfLytely® and Bisacodyl Tablet Bowel Prep Kit for Colon Cleansing

NCT ID: NCT01427296

Last Updated: 2018-01-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

2154 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-16

Study Completion Date

2014-12-09

Brief Summary

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The purpose of this study is to compare the safety and efficacy of OsmoPrep tablets versus HalfLytely and Bisacodyl Tablet Bowel Prep Kit in subjects who are undergoing colonoscopy.

Detailed Description

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Conditions

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Colon Cleansing

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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OsmoPrep Tablets

Group Type ACTIVE_COMPARATOR

Oral sodium phosphate solution

Intervention Type DRUG

OsmoPrep tablets (48 g), administered as 32 total tablets in a total liquid volume of approximately 2 L

HalfLytely and Bisacodyl Tablet

Group Type ACTIVE_COMPARATOR

Polyethylene glycol

Intervention Type DRUG

HalfLytely and Bisacodyl Tablet Bowel Prep Kit, administered as 1 bisacodyl tablet followed by HalfLytely oral solution in a total liquid volume of approximately 2 L

Interventions

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Polyethylene glycol

HalfLytely and Bisacodyl Tablet Bowel Prep Kit, administered as 1 bisacodyl tablet followed by HalfLytely oral solution in a total liquid volume of approximately 2 L

Intervention Type DRUG

Oral sodium phosphate solution

OsmoPrep tablets (48 g), administered as 32 total tablets in a total liquid volume of approximately 2 L

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Between 18 and 70 years of age, inclusive
* Scheduled for colonoscopy within 21 days of the screening visit
* Able to swallow tablets the size of a multivitamin without difficulty

Exclusion Criteria

* History of biopsy-proven acute phosphate nephropathy
* Known allergy or hypersensitivity to treatment arms
* History of gastric stapling or bypass procedure or history of gastric retention
* History of any other sodium phosphate preparation within 6 months prior to colonoscopy
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bausch Health Americas, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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San Carlos, California, United States

Site Status

Bristol, Connecticut, United States

Site Status

Macon, Georgia, United States

Site Status

Suwanee, Georgia, United States

Site Status

Hagerstown, Maryland, United States

Site Status

Wyoming, Michigan, United States

Site Status

Mexico, Missouri, United States

Site Status

Vineland, New Jersey, United States

Site Status

Great Neck, New York, United States

Site Status

New York, New York, United States

Site Status

Fayetteville, North Carolina, United States

Site Status

High Point, North Carolina, United States

Site Status

Raleigh, North Carolina, United States

Site Status

Cincinnati, Ohio, United States

Site Status

Mentor, Ohio, United States

Site Status

Plano, Texas, United States

Site Status

Chesapeake, Virginia, United States

Site Status

Bellevue, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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OSBP4011

Identifier Type: -

Identifier Source: org_study_id

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