Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
NCT ID: NCT01493128
Last Updated: 2017-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2010-04-30
2012-07-31
Brief Summary
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1. The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
2. The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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stable sinus rhythm
No interventions assigned to this group
permanent atrial fibrillation
No interventions assigned to this group
paroxysmal atrial fibrillation
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* selected for open heart surgery
* informed consent
Exclusion Criteria
50 Years
85 Years
ALL
No
Sponsors
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Norwegian University of Science and Technology
OTHER
Responsible Party
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Principal Investigators
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Ulrik Wisløff, PhD
Role: STUDY_DIRECTOR
Norwegian University of Science and Technology
References
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Slagsvold KH, Johnsen AB, Rognmo O, Hoydal MA, Wisloff U, Wahba A. Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. Physiol Genomics. 2014 Jul 15;46(14):505-11. doi: 10.1152/physiolgenomics.00042.2014. Epub 2014 May 13.
Other Identifiers
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ABJ01
Identifier Type: -
Identifier Source: org_study_id
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