Study Results
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View full resultsBasic Information
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COMPLETED
NA
202 participants
INTERVENTIONAL
2010-05-31
2012-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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high saturated fat diet
SFA diet
Volunteers are following a high saturated fat diet for a 4-month period
high monounsaturated fat diet
MUFA diet
Volunteers are following a high monounsaturated fat diet for a 4-month period
high n-6 polyunsaturated fat diet
n-6 PUFA diet
Volunteers are following a high n-6 polyunsaturated fat diet for a 4-month period
Interventions
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SFA diet
Volunteers are following a high saturated fat diet for a 4-month period
MUFA diet
Volunteers are following a high monounsaturated fat diet for a 4-month period
n-6 PUFA diet
Volunteers are following a high n-6 polyunsaturated fat diet for a 4-month period
Eligibility Criteria
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Inclusion Criteria
* total cholesterol (TC) \> 6.0 mmol/l
* HDL cholesterol (HDLC) ≤ 1.0 mmol/l male, ≤ 1.3 mmol/l female
* Glucose ≥ 6 mmol/l
* Stage 1 hypertension or above i.e. a systolic BP ≥ 140 mmHg, diastolic BP ≥ 90 mmHg
* BMI 28-35 kg/m2
* waist \>102 cm male or \> 84 cm female
* Adults with a first degree relative with either a history of premature CVD - age of onset younger than 55 y in fathers, sons or brothers or younger than 65 y in mothers, daughters or sisters, or type 2 diabetes.
Exclusion Criteria
* diabetic (diagnosed or fasting glucose \> 7 mmol/l) or suffer from other endocrine disorders
* suffering from renal or bowel disease or have a history of choleostatic liver or pancreatitis
* on drug treatment for hyperlipidaemia, hypertension, inflammation or hypercoagulation
* no history of alcohol abuse
* planning or on a weight reducing regime
* taking any fish oil, fatty acid or vitamin and mineral supplements
* pregnant, lactating or planning a pregnancy
* smokers
21 Years
60 Years
ALL
No
Sponsors
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University of Reading
OTHER
Responsible Party
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Julie Lovegrove
Professor
Principal Investigators
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Julie A Lovegrove, BSc PhD RNutr
Role: PRINCIPAL_INVESTIGATOR
University of Reading
Locations
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Department of Food and Nutritional Sciences, University of Reading
Reading, Berkshire, United Kingdom
University of Reading
Reading, Berkshire, United Kingdom
Countries
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References
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Sellem L, Eichelmann F, Jackson KG, Wittenbecher C, Schulze MB, Lovegrove JA. Replacement of dietary saturated with unsaturated fatty acids is associated with beneficial effects on lipidome metabolites: a secondary analysis of a randomized trial. Am J Clin Nutr. 2023 Jun;117(6):1248-1261. doi: 10.1016/j.ajcnut.2023.03.024. Epub 2023 Apr 11.
Weech M, Altowaijri H, Mayneris-Perxachs J, Vafeiadou K, Madden J, Todd S, Jackson KG, Lovegrove JA, Yaqoob P. Replacement of dietary saturated fat with unsaturated fats increases numbers of circulating endothelial progenitor cells and decreases numbers of microparticles: findings from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study. Am J Clin Nutr. 2018 Jun 1;107(6):876-882. doi: 10.1093/ajcn/nqy018.
Shatwan IM, Weech M, Jackson KG, Lovegrove JA, Vimaleswaran KS. Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk. Lipids Health Dis. 2017 Nov 23;16(1):222. doi: 10.1186/s12944-017-0606-3.
Vafeiadou K, Weech M, Altowaijri H, Todd S, Yaqoob P, Jackson KG, Lovegrove JA. Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study. Am J Clin Nutr. 2015 Jul;102(1):40-8. doi: 10.3945/ajcn.114.097089. Epub 2015 May 27.
Weech M, Vafeiadou K, Hasaj M, Todd S, Yaqoob P, Jackson KG, Lovegrove JA. Development of a food-exchange model to replace saturated fat with MUFAs and n-6 PUFAs in adults at moderate cardiovascular risk. J Nutr. 2014 Jun;144(6):846-55. doi: 10.3945/jn.114.190645. Epub 2014 Apr 9.
Other Identifiers
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N02044
Identifier Type: -
Identifier Source: org_study_id
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