Finger Muscle Reaction After Electrical Stimuli to the Human Finger Pulley System; a Pilot Study

NCT ID: NCT01456871

Last Updated: 2013-05-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 6 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-08-31
• Study Completion Date: 2012-03-31

Brief Summary

The purpose of the study is to gain a better understanding of mechanoreceptors in the PIP joint ligamento-muscular reflexes and their role is.

Detailed Description

Encapsulated nerve endings called mechanoreceptors are end components of afferent nerves and have specialized end organs surrounding the nerve terminal. Those receptors are concentrated in various human periarticular tissues. It is believed that these mechanoreceptors in the periarticular tissues are related to muscle reflexes. However, it is still unknown which type of mechanoreceptors contribute to the muscle reflexes and whether the mechanoreceptors excite and/or inhibit muscle activation. In the investigators previous studies, mechanoreceptors in the human proximal interphalangeal (PIP) joint and surrounding structures have been extensively examined. The investigators have identified that Pacini-like nerve endings in the PIP joint were found in substantial numbers in the junction of the C1 pulley and accessory collateral ligaments. The investigators hypothesize that the Pacini-like nerve endings in the junction of the C1 pulley generate activity in the associated flexor muscle/tendon in the finger.

Conditions

Healthy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy adult females

Females, aged 20 to 30 with no history of upper extremity injury or disorder in the non-dominant arm, no history of neurologic or bleeding disorder, and no evidence of Linburg-Comstock syndrome.

Guided insertion of electrodes

Intervention Type: PROCEDURE

Fine-wire needle electrodes (30mm x 27gauge needle with a pairs of 0.051mm, insulated, hooked wires, Motion Lab Systems, Baton Rouge, LA) guided by sonographic evaluation of the pulley system using a Philips iU22 Ultrasound Machine (Philips Ultrasound Systems, Bothell, WA), a 17-5 MHz linear array transducer, and standard ultrasound gel.

Electromyographic (EMG) recording

Intervention Type: PROCEDURE

EMG signal recording, performed with an MA 300 EMG system (Motion Lab Systems, Baton Rouge, LA).

Interventions

Guided insertion of electrodes

Fine-wire needle electrodes (30mm x 27gauge needle with a pairs of 0.051mm, insulated, hooked wires, Motion Lab Systems, Baton Rouge, LA) guided by sonographic evaluation of the pulley system using a Philips iU22 Ultrasound Machine (Philips Ultrasound Systems, Bothell, WA), a 17-5 MHz linear array transducer, and standard ultrasound gel.

Intervention Type: PROCEDURE

Electromyographic (EMG) recording

EMG signal recording, performed with an MA 300 EMG system (Motion Lab Systems, Baton Rouge, LA).

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Females aged 20-30

Exclusion Criteria

• A history of any upper extremity injury or disorder in the non-dominant arm
• A history of any neurologic or bleeding disorder, or taking blood-thinning medication.
• Presence of Linbug-Comstock syndrome

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Mayo Clinic

OTHER

Sponsor Role: lead

Responsible Party

Richard A. Berger

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Richard Berger, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Countries

United States

Other Identifiers

11-004310

Identifier Type: -

Identifier Source: org_study_id