Effects of NMES on Energy Expenditure, Glycaemia and Hormonal Responses to Glucose Ingestion

NCT ID: NCT04389736

Last Updated: 2020-05-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 9 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-11-27
• Study Completion Date: 2019-01-20

Brief Summary

The purpose of this study is to investigate whether self-selected neuromuscular stimulation (NMES) affects energy expenditure, glycaemia and hormonal responses in healthy men and women

Detailed Description

Participants were asked to perform 3 trials [sitting (SIT), standing (STAND) and sitting with neuromuscular electrical stimulation (NMES) to the lower limbs in randomised counter-balanced study design. Trials were separated by at least 48 h and were completed within 14 days. In all trials, participants were required to remain relaxed and motionless. SIT: participants sat in a chair with back, arms and legs supported. STAND: participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. If needed, adjustment of standing posture was allowed during the standing trial to prevent orthostatic hypotension. NMES: prior to the NMES trial, participants underwent preliminary testing to ensure that stimulation was comfortable. Before the NMES, a small area of the body hair was shaved and skin was cleaned with an alcohol wipe and electrodes were stuck to the surface of the skin. Small electrodes placed (5*5 cm) on the lower limb of both legs (gastrocnemius, rectus femoris, vastus medialis). The two devices (EM 80, Beurer UK Ltd, Golborne, UK) were set up with the frequency of 20 Hz along with stimulation period of 1 second on and 1 second off throughout a 2 h oral glucose tolerance test (OGTT). The instruction for NMES intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching TV without feeling discomfort. Prior to the OGTT, 5 min was given to identify the suitable intensity of stimulation and within the first 10 min of the OGTT participants were allowed to adjust the intensity once, after which, the intensity remained the same for the rest of OGTT. Participants were asked to sit in a chair with back, arms and legs supported during the stimulation. During trials, participants could watch TV, or read, but typing on a laptop or computer were avoided.

Conditions

Energy Expenditure; Metabolic Health

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

SIT

Sitting

Group Type: EXPERIMENTAL

Sitting

Intervention Type: BEHAVIORAL

Participants sat in a chair with back, arms and legs supported.

STAND

Standing

Group Type: EXPERIMENTAL

Standing

Intervention Type: BEHAVIORAL

Participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. If needed, adjustment of standing posture was allowed during standing trial to prevent orthostatic hypotension.

NMES

Self-selected maximal intensity of neuromuscular electrical stimulation

Group Type: EXPERIMENTAL

Self-selected maximal intensity of neuromuscular electrical stimulation

Intervention Type: BEHAVIORAL

Small electrodes placed (5\*5 cm) on the lower limb of both legs. The instruction for NMES intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching TV without feeling discomfort.

Interventions

Sitting

Participants sat in a chair with back, arms and legs supported.

Intervention Type: BEHAVIORAL

Standing

Participants were asked to stand with arms supported and feet spaced approximately 15 cm apart. If needed, adjustment of standing posture was allowed during standing trial to prevent orthostatic hypotension.

Intervention Type: BEHAVIORAL

Self-selected maximal intensity of neuromuscular electrical stimulation

Small electrodes placed (5\*5 cm) on the lower limb of both legs. The instruction for NMES intensity was that the maximal intensity participants were be able to withstand for 2 hours whilst imagining sitting at home watching TV without feeling discomfort.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Healthy men and women
• Aged between 18 to 65 years
• Weight stable for more than 3 months (no change in weight +/- 3%)
• Non-smoker

Exclusion Criteria

• Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
• Taking medications that may influence lipid or carbohydrate metabolism or immune system function

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Bath

OTHER

Sponsor Role: collaborator

National Taiwan Normal University

OTHER

Sponsor Role: lead

Responsible Party

Yung-Chih Chen

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

National Taiwan Normal University

Taipei, , Taiwan

Countries

Taiwan

References

Chen Y.-C., Davies R.G., Hengist A., Carroll H.A., Perkin O.J., Betts J.A., Thompson D.. Effects of neuromuscular electrical stimulation on energy expenditure and postprandial metabolism in healthy men. Appl Physiol Nutr Metab. 2022 Jan;47(1):27-33. doi: 10.1139/apnm-2021-0361. Epub 2021 Aug 17.

Reference Type: DERIVED

PMID: 34403626 (View on PubMed)

Other Identifiers

EP 17/18 230

Identifier Type: -

Identifier Source: org_study_id