APOL1 Gene Variants in African American Kidney Transplant Recipients
NCT ID: NCT01442402
Last Updated: 2021-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
39 participants
OBSERVATIONAL
2014-04-30
2014-04-30
Brief Summary
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Determine if there is an association between the APOL1 risk variants and allograft survival and function in African Americans
Aim 2:
Determine if there is an association between the presence of APOL1 risk variants in an African American kidney transplant recipient and the risk of recurrent disease
Aim 3:
Investigate mechanisms of APOL1 associated kidney disease by prospectively following African American kidney transplant recipients throughout their clinical course.
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Detailed Description
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Conditions
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Study Design
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COHORT
OTHER
Study Groups
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2 APOL1 genotypes
African American transplant recipients with homozygous APOL1 gene variants
No interventions assigned to this group
0 or 1 APOL1 genotypes
African American transplant recipients without homozygous APOL1 gene variants
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* 18 years or older
* kidney transplant within 12 years
Aim 2:
* self-reported African American
* 18 years or older
* kidney transplant within 12 years
* recurrent or de novo glomerular disease on allograft kidney biopsy
* self-reported African American
* 18 years or older
* kidney transplant within 12 years
* end stage kidney disease due to glomerular nephritis, clinically diagnosed or by native kidney biopsy
* self-reported African American
* 18 years or older
* scheduled living kidney transplant
Exclusion Criteria
Aim 3:
18 Years
ALL
No
Sponsors
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Brigham and Women's Hospital
OTHER
Responsible Party
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Anil K. Chandraker, MD
Medical Director of Renal Transplantation
Principal Investigators
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Anil K Chandraker, MD
Role: PRINCIPAL_INVESTIGATOR
Brigham and Women's Hospital
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, United States
Countries
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Other Identifiers
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2011P000734
Identifier Type: -
Identifier Source: org_study_id
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