Diagnosing Pulmonary Aspergillosis in Patients With Hematological Malignancies: A Multicentre Prospective Evaluation of an Aspergillus PCR Assay and a Galactomannan ELISA in Bronchoalveolar Lavage Samples
NCT ID: NCT01430663
Last Updated: 2020-04-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
87 participants
OBSERVATIONAL
2007-04-30
2011-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Hematological patients with proven or probable aspergillosis
No interventions assigned to this group
Hematological patients with possible aspergillosis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
5 Years
80 Years
ALL
No
Sponsors
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Heidelberg University
OTHER
Responsible Party
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Dieter Buchheidt
Prof. Dr. med.
Principal Investigators
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Dieter Buchheidt, MD
Role: PRINCIPAL_INVESTIGATOR
Mannheim University Hospital
Locations
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Innsbruck University Hospital
Innsbruck, , Austria
Cologne University Hospital
Cologne, , Germany
Erlangen University Hospital
Erlangen, , Germany
General Hospital Frankfurt (Oder)
Frankfurt (Oder), , Germany
Freiburg University Hospital
Freiburg im Breisgau, , Germany
Halle University Hospital
Halle, , Germany
Herne University Hospital
Herne, , Germany
Mannheim University Hospital
Mannheim, , Germany
Würzburg University Hospital
Würzburg, , Germany
Countries
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References
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Skladny H, Buchheidt D, Baust C, Krieg-Schneider F, Seifarth W, Leib-Mosch C, Hehlmann R. Specific detection of Aspergillus species in blood and bronchoalveolar lavage samples of immunocompromised patients by two-step PCR. J Clin Microbiol. 1999 Dec;37(12):3865-71. doi: 10.1128/JCM.37.12.3865-3871.1999.
Buchheidt D, Baust C, Skladny H, Ritter J, Suedhoff T, Baldus M, Seifarth W, Leib-Moesch C, Hehlmann R. Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results. Clin Infect Dis. 2001 Aug 15;33(4):428-35. doi: 10.1086/321887. Epub 2001 Jul 6.
Spiess B, Buchheidt D, Baust C, Skladny H, Seifarth W, Zeilfelder U, Leib-Mosch C, Morz H, Hehlmann R. Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients. J Clin Microbiol. 2003 May;41(5):1811-8. doi: 10.1128/JCM.41.5.1811-1818.2003.
Hummel M, Spiess B, Cornely OA, Dittmer M, Morz H, Buchheidt D. Aspergillus PCR testing: results from a prospective PCR study within the AmBiLoad trial. Eur J Haematol. 2010 Aug;85(2):164-9. doi: 10.1111/j.1600-0609.2010.01452.x. Epub 2010 Apr 1.
Other Identifiers
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AGIHO BAL GM PCR 2007
Identifier Type: -
Identifier Source: org_study_id
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