Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis
NCT ID: NCT01430026
Last Updated: 2015-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
40 participants
OBSERVATIONAL
2011-03-31
2012-03-31
Brief Summary
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Detailed Description
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Two or more symptoms one of which should be either nasal blockage /obstruction/congestion or nasal discharge (anterior/posterior nasal drip):
* facial pain/pressure
* reduction or loss of smell)
Mainstay of treatment are medical and surgical treatment ( ATB, adenoidectomy, ESS) Adjunctive treatment : normal saline nasal irrigation, nasal corticosteroids, nasal decongestants, mucolytics Topical antibiotic therapy in patients with refractory sinusitis has been shown to improve symptoms, quality of life, and mucosal aspect Nasal lavage with Mupirocin represent an effective and well tolerated alternative treatment of surgically recalcitrant chronic rhinosinusitis
In pediatrics allergy clinic at Siriraj hospital since 2006 use Gentamicin nasal irrigation for chronic rhinosinusitis.There have been no studies in gentamicin irrigation in chronic rhinosinusitis. The aims of this study are to evaluate:
1. Efficacy of gentamicin nasal irrigation in chronic rhinosinusitis (outcomes: frequency of sinusitis, frequency of antibiotic usage)
2. Complication of gentamicin nasal irrigation usage
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Gentamicin nasal irrigation usage for longer than 3 months
Exclusion Criteria
* Patients received IVIG within 1 year before and 6 months after started gentamicin nasal irrigation
* Patients underwent endoscopic sinus surgery within 1 year before and 6 months after started gentamicin nasal irrigation
* Patients received IT within 1 year before and 6 months after started gentamicin nasal irrigation
ALL
No
Sponsors
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Mahidol University
OTHER
Responsible Party
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Nualanong Visitsunthorn
Professor
Principal Investigators
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Nualanong Visitsunthorn, professor
Role: PRINCIPAL_INVESTIGATOR
Department of Pediatrics Faculty of Medicine Siriraj Hospital, Mahidol University
Locations
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Faculty of Medicine Siriraj Hospital
Bangkoknoi, Bangkok, Thailand
Countries
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References
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Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl. 2007;20:1-136.
Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg. 2001 Sep;125(3):265-9. doi: 10.1067/mhn.2001.117410.
Uren B, Psaltis A, Wormald PJ. Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis. Laryngoscope. 2008 Sep;118(9):1677-80. doi: 10.1097/MLG.0b013e31817aec47.
Other Identifiers
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004/2554(EC3)
Identifier Type: -
Identifier Source: org_study_id
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