Adjuvanted Influenza Vaccine Effectiveness in the Elderly (65+Yrs)

NCT ID: NCT01424371

Last Updated: 2012-10-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2013-06-30

Brief Summary

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This study explores the hypothesis that the use of an adjuvanted influenza vaccine in the elderly will produce greater vaccine effectiveness in their group.

Detailed Description

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To evaluate the effectiveness of adjuvanted trivalent inactivated influenza vaccine in the elderly (aged ≥ 65 years) through the reduction in relative risk of microbiologically confirmed influenza illness

Conditions

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Influenza

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Adjuvanted Vaccine Group

No interventions assigned to this group

Unadjuvanted Vaccine Group

No interventions assigned to this group

Unvaccinated Elderly

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1.Elderly tested for influenza as part of routine clinical care in the Lower Mainland and on Vancouver Island during the influenza season.

Cases: Proven influenza diagnosed on naso-pharyngeal swab via PCR Controls: Elderly with influenza-like-illness testing negative for influenza during the influenza season.

Exclusion Criteria

1. Known immunodeficiency disorders (including HIV)
2. Current or recent (within 90 days prior to first dose of influenza vaccine) immunosuppressive treatment including chronic oral steroids (1mg/kg for \> 4 weeks), cytotoxic chemotherapy, radiation therapy, other immunosuppressive drug and biologic agents Note: Use of topical or inhalant corticosteroids is acceptable.
3. Administration of immunoglobulins during the study period;
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role collaborator

Fraser Health

OTHER

Sponsor Role lead

Responsible Party

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Paul VanBuynder

Chief Medical Health Officer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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PAUL G VAN BUYNDER, MBBS MPH

Role: PRINCIPAL_INVESTIGATOR

Fraser Health Authority

Locations

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Fraser Health Authority

Surrey, British Columbia, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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PAUL G VAN BUYNDER, MBBS MPH

Role: CONTACT

Phone: 6044187497

Email: [email protected]

Other Identifiers

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2011-071

Identifier Type: -

Identifier Source: org_study_id