Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography
NCT ID: NCT01419860
Last Updated: 2022-05-02
Study Results
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Basic Information
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COMPLETED
NA
4 participants
INTERVENTIONAL
2010-01-31
2016-12-31
Brief Summary
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Detailed Description
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Microcirculation of colon wall was assessed by dynamic laser-induced-fluorescence-videoangiography (IC-VIEW, PULSION Medical Systems AG, Munich, Germany) of indocyanine green (ICG). ICG is a water-soluble tricarbocyanine dye that binds strongly to plasma proteins after intravenous injection and is exclusively distributed in intravascular space. Additionally this system houses a laser (energy Pi = 0.16 W, wavelength = 780 nm) that causes excitation/illumination of the fluorescence light from intravascular plasma bound ICG. This light has a spectral range near-infrared energy (NIR) with a maximum at 805 nm and emits fluorescence at 835 nm. It passes through infrared filter on a digital video camera and results in recording of real time fluorescent image from perfusion of plasma bound ICG within small plexus of blood vessels in the bowel wall. Besides that it also demonstrates perfusion from surrounding structures such as appendix epiploic and pericolic fat. The maximum penetration of the laser into tissue is 3-5 mm and general normal thickness of colon wall is 3-5 mm. This method makes it a presentable tracer for tissue perfusion of anterior bowel wall.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Pixel intensity
Pixel intensity of fluorescence signal describing pixel microcirculation of colon
Elective colon resection
In our scientific experiment, we evaluate microcirculation in colon wall and anastomosis with laser induced fluorescence videoangiography of ICG. By implementing this technique we can measure average pixel intensity of fluorescence signal in area of interest on bowel, which represents tissue perfusion in this respective part of intestinal wall.
Interventions
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Elective colon resection
In our scientific experiment, we evaluate microcirculation in colon wall and anastomosis with laser induced fluorescence videoangiography of ICG. By implementing this technique we can measure average pixel intensity of fluorescence signal in area of interest on bowel, which represents tissue perfusion in this respective part of intestinal wall.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Children or patients below the age of 18 years
* Advanced renal or hepatic failure
* Previous allergic reactions to ICG and iodide
* Chronic anemia
* Active haematologic disease
* Women of fertile age needed a negative pregnancy test to be included
* Patients with previous colectomy or anorectal surgery were also excluded due to anatomical insult on mesenterial circulation
18 Years
ALL
No
Sponsors
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Ostfold Hospital Trust
OTHER
Responsible Party
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Principal Investigators
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Muiz A. Chaudhry, MD
Role: PRINCIPAL_INVESTIGATOR
Ostfold Hospital Trust HF
Locations
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Østfold Hospital Trust HF
Fredrikstad, Østfold fylke, Norway
Countries
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References
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Related Links
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Other Identifiers
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Microcirculation of colon
Identifier Type: -
Identifier Source: org_study_id
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