The Health Effect of Diet Rich in Nordic Berries

NCT ID: NCT01414647

Last Updated: 2018-05-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 56 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-01-31
• Study Completion Date: 2010-03-31

Brief Summary

Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.

Detailed Description

Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.

The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.

Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.

Conditions

Metabolic Syndrome; Impaired Glucose Tolerance; Low-grade Inflammation; Dyslipidemia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

SRC

Strawberry, raspberry and cloudberry intervention for 8 weeks

Group Type: EXPERIMENTAL

300 g of strawberry, raspberry and cloudberry

Intervention Type: DIETARY_SUPPLEMENT

100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.

BB

Bilberry intervention for 8 weeks

Group Type: EXPERIMENTAL

400 g of bilberry

Intervention Type: DIETARY_SUPPLEMENT

Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.

C

Control diet with restricted berry consumption

Group Type: EXPERIMENTAL

Control diet

Intervention Type: OTHER

Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

Interventions

300 g of strawberry, raspberry and cloudberry

100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.

Intervention Type: DIETARY_SUPPLEMENT

400 g of bilberry

Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.

Intervention Type: DIETARY_SUPPLEMENT

Control diet

Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

Intervention Type: OTHER

Other Intervention Names

Diet with restricted consumption of berries.

Eligibility Criteria

Inclusion Criteria

• overweight (BMI 26-39 kg/m2), and two of the following:
• elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
• abnormal serum lipid concentration: fasting serum triglyceride concentration >1.7 mmol/L, fasting serum HDL cholesterol <1.0 mmol/L (males) or <1.3 mmol/L (females))
• waist circumference >102 cm (males) or >88 cm (females)
• blood pressure >130/85 mmHg

Exclusion Criteria

• chronic diseases
• use of lipid lowering medication

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

VTT Technical Research Centre, Finland

OTHER

Sponsor Role: collaborator

Marjukka Kolehmainen

OTHER

Sponsor Role: lead

Responsible Party

Marjukka Kolehmainen

Senior scientist

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Riitta Törrönen, Adjunct Professor

Role: PRINCIPAL_INVESTIGATOR

University of Eastern Finland

Locations

University of Eastern Finland, Dpet of Public Health and Clinical Nutrition

Kuopio, , Finland

Countries

Finland

References

Puupponen-Pimia R, Seppanen-Laakso T, Kankainen M, Maukonen J, Torronen R, Kolehmainen M, Leppanen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tomas-Barberan FA, Espin JC, Oksman-Caldentey KM. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12.

Reference Type: DERIVED

PMID: 23934737 (View on PubMed)

Kolehmainen M, Mykkanen O, Kirjavainen PV, Leppanen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimia R, Pulkkinen L, Mykkanen H, Gylling H, Poutanen K, Torronen R. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res. 2012 Oct;56(10):1501-10. doi: 10.1002/mnfr.201200195. Epub 2012 Sep 7.

Reference Type: DERIVED

PMID: 22961907 (View on PubMed)

Other Identifiers

40361/05

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

124//2005

Identifier Type: -

Identifier Source: org_study_id