Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy
NCT ID: NCT01413945
Last Updated: 2019-02-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
2 participants
OBSERVATIONAL
2013-06-21
2017-01-18
Brief Summary
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The primary objective is to measure the pressure of the ileocecal valve in patients with and without irritable bowel syndrome (IBS). The Ileocecal valve reflux pressures during air insufflation of cecum will be used.
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Detailed Description
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Based on questionnaire we plan to recruit 25 participants who meet the criteria of IBS and 25 participants who do not meet the criteria of IBS (Total of 50 participants in the study). Patients with IBS are those who meet the criteria of IBS based on their symptoms and the responses to a validated ROME III - questionnaire. All other participants who do not meet the criteria for IBS are classified as non-IBS participants. All the participants should be having a clinically indicated colonoscopy.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Normal volunteers
Normal volunteers without Irritable bowel syndrome who are undergoing screening colonoscopy.
No interventions assigned to this group
Irritable bowel syndrome
Patients with Irritable bowel syndrome are undergoing colonoscopy as standard of care.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
20 Years
80 Years
ALL
Yes
Sponsors
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Northwell Health
OTHER
Responsible Party
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Larry Miller
Principal Investigator
Principal Investigators
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Larry S Miller, MD
Role: PRINCIPAL_INVESTIGATOR
Northwell Health
Locations
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LIJ Medical Center- NSLIJ Health System
New Hyde Park, New York, United States
Countries
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References
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GAZET RJ, JARRETT J. THE ILEOCAECO-COLIC SPHINCTER. STUDIES IN VITRO IN MAN, MONKEY, CAT, AND DOG. Br J Surg. 1964 May;51:368-70. doi: 10.1002/bjs.1800510519. No abstract available.
SINGLETON AO Jr, REDMOND DC 2nd, MCMURRAY JE. ILEOCECAL RESECTION AND SMALL BOWEL TRANSIT AND ABSORPTION. Ann Surg. 1964 May;159(5):690-4. doi: 10.1097/00000658-196405000-00006. No abstract available.
Jarrett RJ, Gazet JC. Studies in vivo of the ileocaeco-colic sphincter in the cat and dog. Gut. 1966 Jun;7(3):271-5. doi: 10.1136/gut.7.3.271. No abstract available.
Kelley ML Jr, Gordon EA, Deweese JA. Pressure responses of canine ileocolonic junctional zone to intestinal distention. Am J Physiol. 1966 Sep;211(3):614-8. doi: 10.1152/ajplegacy.1966.211.3.614. No abstract available.
Cohen S, Harris LD, Levitan R. Manometric characteristics of the human ileocecal junctional zone. Gastroenterology. 1968 Jan;54(1):72-5. No abstract available.
Castell DO, Cohen S, Harris LD. Response of human ileocecal sphincter to gastrin. Am J Physiol. 1970 Sep;219(3):712-5. doi: 10.1152/ajplegacy.1970.219.3.712. No abstract available.
Griffen WO Jr, Richardson JD, Medley ES. Prevention of small bowel contamination by ileocecal valve. South Med J. 1971 Sep;64(9):1056-8. doi: 10.1097/00007611-197109000-00006. No abstract available.
Pahlin PE, Kewenter J. Sympathetic nervous control of cat ileocecal sphincter. Am J Physiol. 1976 Aug;231(2):296-305. doi: 10.1152/ajplegacy.1976.231.2.296.
Stremmel W, Kurpreugsch K, Langewitz W. [Hormonal and pharmacological modification of the ileocecal sphincter]. Chir Forum Exp Klin Forsch. 1977 Apr:45-8. German.
King CE, Toskes PP. Small intestine bacterial overgrowth. Gastroenterology. 1979 May;76(5 Pt 1):1035-55. No abstract available.
Rubin MR, Fournet J, Snape WJ Jr, Cohen S. Adrenergic regulation of ileocecal sphincter function in the cat. Gastroenterology. 1980 Jan;78(1):15-21. No abstract available.
Other Identifiers
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13-216B
Identifier Type: -
Identifier Source: org_study_id
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