Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

NCT ID: NCT00742118

Last Updated: 2015-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2016-07-31

Brief Summary

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Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:

1. paracellular permeability in colonic biopsies of IBS patient
2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Detailed Description

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Conditions

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Irritable Bowel Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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2

patient with chronic inflammatory intestinal disease

Group Type EXPERIMENTAL

Colic biopsies

Intervention Type PROCEDURE

colic biopsies and analysis

3

patient having no symptoms

Group Type OTHER

Colic biopsies

Intervention Type PROCEDURE

colic biopsies and analysis

1

patient with irritable bowel syndrome

Group Type EXPERIMENTAL

Colic biopsies

Intervention Type PROCEDURE

colic biopsies and analysis

Interventions

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Colic biopsies

colic biopsies and analysis

Intervention Type PROCEDURE

Other Intervention Names

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endoscopic biopsy

Eligibility Criteria

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Inclusion Criteria

* Patients needing coloscopy

Exclusion Criteria

* Disrupted coagulation results
* Cancer even healed
* Known food allergy.
* Alcohol consumption \>30g/day
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation de l'Avenir

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire de Nice

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thierry PICHE, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Gastroenterology

Locations

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Department of gastroenterology, Hopital Archet 2

Nice, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Thierry PICHE, PhD

Role: CONTACT

Facility Contacts

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Thierry PICHE, PhD

Role: primary

Other Identifiers

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05-API-08

Identifier Type: -

Identifier Source: org_study_id

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