Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination

NCT ID: NCT01410552

Last Updated: 2019-03-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1013 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2016-02-29

Brief Summary

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ISIS- ICD study has been designed to evaluate the impact of PARAD+ algorithm on inappropriate shocks, in a general population implanted for primary or secondary prevention with a dual or tri chamber device at one year follow-up

Detailed Description

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The primary endpoint is to demonstrate that 95% of patients implanted with PARAD+ algorithm are free from inapproporiate shock compared to 92.5% in general ICD population.

Conditions

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Tachycardia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

ICD device
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ICD or CRT-D with PARAD+

only 1 arm is the study: all patients implanted with ICD or CRT-D with PARAD+ enabled, no comparator

Group Type OTHER

PARADYM DR model 8550; PARADYM CRT model 8750; PARADYM RF DR model 9550; PARADYM RF CRT model 9750; PARADYM RF CRT SonR model 9770

Intervention Type DEVICE

PARADYM ICD and CRT-d with PARAD+ algorithm available

Interventions

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PARADYM DR model 8550; PARADYM CRT model 8750; PARADYM RF DR model 9550; PARADYM RF CRT model 9750; PARADYM RF CRT SonR model 9770

PARADYM ICD and CRT-d with PARAD+ algorithm available

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient eligible for implantation (according to current accepted guidelines, or scheduled for implant (primo-implant, replacement, upgrade) with a Paradym/Paradym RF (CRT-D or DR-ICD) within the next 30 days, or has already been implanted within the last 30 days
2. Patient in sinus rhythm, or patients with paroxysmal atrial tachyarrhythmia or patients with persistent atrial tachyarrhythmia in whom a cardioversion is planned within three months

Exclusion Criteria

1. Any contraindication for ICD therapy
2. Atrial lead not implanted
3. Patient with permanent atrial tachyarrhythmia
4. Patients implanted with a ventricular assist device (VAD)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MicroPort CRM

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ricardo RUIZ GRANELL, Dr

Role: PRINCIPAL_INVESTIGATOR

Cardiology Department Arrhythmia Unit Hospital Clinico Universitario Valencia SPAIN

Mark RICHARDS, Dr.

Role: PRINCIPAL_INVESTIGATOR

Toledo Hospital, 4614 Brookside Dr. Toledo (OH)

Locations

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Southwest Cardiovascular Associates

Mesa, Arizona, United States

Site Status

Pacific Arrhythmia Services

Mesa, Arizona, United States

Site Status

Banner Arizona Medical Clinic

Peoria, Arizona, United States

Site Status

Banner Good Samaritan Medical Center

Phoenix, Arizona, United States

Site Status

Southern California Electrophysiology Associates

Anaheim, California, United States

Site Status

Raymond H. M. Schaerf MD, Inc.

Burbank, California, United States

Site Status

St. Rose Hospital

Fremont, California, United States

Site Status

H. Raj Reddy Md, Inc.

Hanford, California, United States

Site Status

Broward General Medical Center

Fort Lauderdale, Florida, United States

Site Status

Memorial West Hospital

Pembroke Pines, Florida, United States

Site Status

Medical Center of Central Georgia

Macon, Georgia, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

St. Tammany Hospital

Covington, Louisiana, United States

Site Status

Ochsner Clinic Foundation

New Orleans, Louisiana, United States

Site Status

Louisiana Heart Center

Slidell, Louisiana, United States

Site Status

MGH

Boston, Massachusetts, United States

Site Status

Gulfport Memorial Hospital

Gulfport, Mississippi, United States

Site Status

Harlem Cardiology

New York, New York, United States

Site Status

Pitt Memeorial Hospital Heart Rhythm Associates

Greenville, North Carolina, United States

Site Status

Rex Heart and Vascular Specialists

Raleigh, North Carolina, United States

Site Status

Fairview Hospital

Cleveland, Ohio, United States

Site Status

The Toledo Hospital

Toledo, Ohio, United States

Site Status

Easton Hospital

Easton, Pennsylvania, United States

Site Status

Drexel University College of Medicine

Philadelphia, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Providence Hospital

Columbia, South Carolina, United States

Site Status

Carolina Arrhythmia Consultants

Mt. Pleasant, South Carolina, United States

Site Status

Centre Hospitalier Universitaire D'Amiens

Amiens, , France

Site Status

Clinique Saint Joseph

Angers, , France

Site Status

Chu Annecy

Annecy, , France

Site Status

CH Henri Duffaut - Avignon

Avignon, , France

Site Status

Hôpital Privé de Bois Bernad

Bois-Bernard, , France

Site Status

CHRU du Morvan Hôpital la Cavale Blanche

Brest, , France

Site Status

Hôpital Instruction des Armées

Clamart, , France

Site Status

CH La Rochelle - hôpital St Louis

La Rochelle, , France

Site Status

CH LENS

Lens, , France

Site Status

Hopital Saint Joseph et saint Luc

Lyon, , France

Site Status

Centre Hospitalier Universitaire de La Timone

Marseille, , France

Site Status

Hopital Nord

Marseille, , France

Site Status

CH Montpellier

Montpellier, , France

Site Status

CH Emile Muller

Mulhouse, , France

Site Status

CHU Groupe Hospitalo-universitaire Caremeau

Nîmes, , France

Site Status

Hôpital Pitié-Salpêtrière

Paris, , France

Site Status

Hôpital Européen Georges Pompidou

Paris, , France

Site Status

Centre Hospitalier

Pau, , France

Site Status

CH Périgueux

Périgueux, , France

Site Status

CH Yves le Foll

Saint-Brieuc, , France

Site Status

Centre Hospitalier de Valence

Valence, , France

Site Status

CHU Brabois

Vandœuvre-lès-Nancy, , France

Site Status

Klinikum Bogenhausen

Bogenhausen, , Germany

Site Status

Universitatsklinikum Schleswig-Holstein Campus Lübeck

Lübeck, , Germany

Site Status

UKSH Campus Luebeck

Lübeck, , Germany

Site Status

Klinik für Kardiologie Städtisches Klinikum Lüneburg gGmbH

Lüneburg, , Germany

Site Status

Kardiologische Praxis Dr. med Taggeselle

Markkleeberg, , Germany

Site Status

DRK Krankenhaus Ratzeburg

Ratzeburg, , Germany

Site Status

Policlinico Consorziale di Bari U.O Cardiologia Universitaria

Bari, , Italy

Site Status

Po Melorio

Santa Maria Capua Vetere, , Italy

Site Status

Ospedale S.Andrea

Vercelli, , Italy

Site Status

Chiba University Hospital

Chiba, , Japan

Site Status

Ichinomiya Nishi Hospital

Ichinomiya, , Japan

Site Status

Iizuka Hospital

Iizuka, , Japan

Site Status

Yamanashi Prefectural Central Hospital

Kofu, , Japan

Site Status

Kokura Memorial Hospital

Kokura, , Japan

Site Status

Ohtanishinouchi Hospital

Kōriyama, , Japan

Site Status

Shin-Tokyo Hospital

Tokyo, , Japan

Site Status

Tokyo Medical and Dental University Hospital

Tokyo, , Japan

Site Status

Tokyo Metropolitan Hiroo Hospital

Tokyo, , Japan

Site Status

Tokai University School of Medicine

Tōkai, , Japan

Site Status

Yamaguchi University Hospital

Ube, , Japan

Site Status

Yokohama City University Hospital

Yokohama, , Japan

Site Status

Yokohama Rosai general Hospital

Yokosuka, , Japan

Site Status

Hospital Universitario de la Ribera

Alzira, , Spain

Site Status

Hospital Germans Trias i Pujol

Badalona, , Spain

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

CHU VIGO

Vigo, , Spain

Site Status

Basildon University Hospital

Basildon, England, United Kingdom

Site Status

Blackpool Victoria Hospital

Blackpool, , United Kingdom

Site Status

Papworth Everard

Cambridge, , United Kingdom

Site Status

Dorset County Hospital

Dorchester, , United Kingdom

Site Status

Kettering Hospital

Kettering, , United Kingdom

Site Status

Countries

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United States France Germany Italy Japan Spain United Kingdom

References

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Ruiz-Granell R, Dovellini EV, Dompnier A, Khalighi K, Garcia-Campo E, Olivier A, Barcelo A, Ritter P. Algorithm-based reduction of inappropriate defibrillator shock: Results of the Inappropriate Shock Reduction wIth PARAD+ Rhythm DiScrimination-Implantable Cardioverter Defibrillator Study. Heart Rhythm. 2019 Sep;16(9):1429-1435. doi: 10.1016/j.hrthm.2019.03.016. Epub 2019 Mar 22.

Reference Type DERIVED
PMID: 30910709 (View on PubMed)

Other Identifiers

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ISIS ICD - ITSY09

Identifier Type: -

Identifier Source: org_study_id

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