A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

NCT ID: NCT01386229

Last Updated: 2011-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2012-03-31

Brief Summary

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The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Detailed Description

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Conditions

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Coronary Artery Bypass Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Ketamine

Group Type ACTIVE_COMPARATOR

Ketamine

Intervention Type DRUG

During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered

Etomidate

Group Type ACTIVE_COMPARATOR

Etomidate

Intervention Type DRUG

During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered

Interventions

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Ketamine

During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered

Intervention Type DRUG

Etomidate

During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
* Patient's written informed consent for study participation
* Ejection fraction ≥ 35%

Exclusion Criteria

* Allergy to study drugs
* Redo surgery
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Baskent University

OTHER

Sponsor Role lead

Responsible Party

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Baskent University, Faculty of Medicine

Principal Investigators

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Özgür Kömürcü

Role: PRINCIPAL_INVESTIGATOR

Baskent University, Faculty of Medicine

Locations

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Baskent University, Faculty of Medicine

Ankara, Çankaya, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Özgür Kömürcü

Role: CONTACT

+90 312 215 99 41

Arash Pirat

Role: CONTACT

+90 312 212 68 68 ext. 1800

Other Identifiers

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KA-10-114

Identifier Type: -

Identifier Source: org_study_id

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