Prognostic Impact of an Oral Triglyceride Tolerance Test in Patients After Acute Ischemic Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

573 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2017-07-31

Brief Summary

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Non-fasting triglyceride levels are thought to play a role in stroke. The investigators hypothesise that the results of a standardised oral triglyceride tolerance test in the subacute setting (3-7 days) after the first ischaemic stroke are associated with the risk of recurrent stroke within 12 months after the index event.

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Detailed Description

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Since high postprandial triglycerides levels may be a risk factor for stroke, we use a combined oral triglyceride and glucose tolerance test in patients who had a first ischemic stroke. Follow-up after one year primarily assesses wether or not a recurrent stroke has occured. The glucose tolerance test is meant to identify patients with metabolic syndrome (and diabetes), since this condition is per se associated with increased levels of triglycerides. Potentially, the post-challenge triglyceride levels only play a role in patients without diabetes or metabolic syndrome. For further details see Ebinger et al. 'The Berlin 'Cream\&Sugar' Study: the prognostic impact of an oral triglyceride tolerance test in patients after acute ischaemic stroke', IJS; 2010,5, 47-51.

Conditions

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First Ischemic Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with first ischemic stroke

oral triglyceride tolerance test (not a therapeutic "intervention" as such but a new diagnostic test)

Intervention Type OTHER

see Ebinger et al., IJS, 2010

Interventions

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oral triglyceride tolerance test (not a therapeutic "intervention" as such but a new diagnostic test)

see Ebinger et al., IJS, 2010

Intervention Type OTHER

Other Intervention Names

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cream

Eligibility Criteria

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Inclusion Criteria

* Age over 18 years
* First ischemic stroke
* Incidence within less than 7 days
* Informed consent obtained

Exclusion Criteria

* Aphasia (if hampering informed consent)
* Swallowing disorder
* Pregnancy
* Renal or hepatic failure
* Pancreatitis
* Cholecystolithiasis
* Malabsorption
* Lactose intolerance
* Psychosis
* Drug and/or alcohol addiction
* Expected life expectancyr12 months
* Inability to sign informed consent
* Acute coronary syndrome
* Severe heart valve disorder
* Heart failure (NYHA III-IV)
* Severe infectious/rheumatic disease
* Sever metabolic disease
* No oral glucose tolerance test in case of known diabetes

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No