Acceptability and Effectiveness of Household Water Treatment in Reducing Diarrhea Among Under Five Children

NCT ID: NCT01376440

Last Updated: 2012-01-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 845 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-06-30
• Study Completion Date: 2011-10-31

Brief Summary

The Millenium development goals (MDGs) call for reducing by half the proportion of people without sustainable access to safe drinking water. This goal was adopted in large part because safe drinking water has been seen as critical to fighting diarrheal disease. Source protection is considered the main intervention area to achieve this goal. However, research worldwide that has shown that even drinking water which is safe at the source is subject to frequent and extensive fecal contamination during collection, storage and use in the home. This contamination is through the introduction of cups, dippers or hands, contamination by flies, cockroaches, and rats. Even piped water supplies of adequate microbial quality can pose infectious disease risks if they become contaminated due to unsanitary collection, storage conditions and practices within households.

To reduce this problem, point-of-use water treatment has been advocated as a means to substantially decrease the global burden of diarrhea and to contribute to the MDGs. However, research indicates that there are many unanswered questions around Household water treatment (HWT) that require small or medium scale epidemiological studies and randomized controlled trials, especially with regard to effectiveness, acceptability and identifying suitable target populations. Some of the most urgent questions to be resolved are:(1) How much of the currently cited disease reduction of HWT is due to bias? (2) What is the effect of HWT on nutritional status (weight gain and growth)?(3) At which populations should HWT be targeted? (4) Is it acceptable and sustainable in poor communities where the risk of diarrheal disease is high.

hypothesis: Do household water treatment with chlorine reduce diarrhea among underfive children? hypothesis: Do household water treatment with chlorine acceptable in the community?

Conditions

Acute Diarrhoea

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Household water treatment

household water treatment with 1.25% sodium hypochlorite

Group Type: EXPERIMENTAL

household water treatment

Intervention Type: OTHER

household water treatment with 1.25% sodium hypochlorite

control

Usual practice (the use of "Jerrican" for water storage, which is considered as safe storage)

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

household water treatment

household water treatment with 1.25% sodium hypochlorite

Intervention Type: OTHER

Other Intervention Names

1.25% sodium hypochlorite

Eligibility Criteria

Inclusion Criteria

• All children under five years of age in the randomly selected clusters of Kersa district

Exclusion Criteria

• seriously sick children in the randomly selected clusters of Kersa district

• Minimum Eligible Age: 1 Month
• Maximum Eligible Age: 59 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Haramaya Unversity

OTHER

Sponsor Role: lead

Responsible Party

Bezatu Mengiste

Mr

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Bezatu M Alemu, M.Sc

Role: PRINCIPAL_INVESTIGATOR

Assistant professor

Locations

Kersa district

Kersa, Eastern Hararage, Ethiopia

Countries

Ethiopia

References

Mengistie B, Berhane Y, Worku A. Household water chlorination reduces incidence of diarrhea among under-five children in rural Ethiopia: a cluster randomized controlled trial. PLoS One. 2013 Oct 23;8(10):e77887. doi: 10.1371/journal.pone.0077887. eCollection 2013.

Reference Type: DERIVED

PMID: 24194899 (View on PubMed)

Other Identifiers

SGS13/15/11

Identifier Type: -

Identifier Source: org_study_id