Unrelated Donor Stem Cell Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2015-07-31

Brief Summary

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The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.

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Detailed Description

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same

Conditions

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Severe Aplastic Anemia Paroxysmal Nocturnal Hemoglobinuria Acute Myelogenous Leukemia Acute Lymphoblastic Leukemia Myelodysplastic Syndromes Myeloproliferative Syndromes Chronic Myelogenous Leukemia Hodgkin's Lymphoma Non-Hodgkin's Lymphoma Multiple Myeloma Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma Large Granulocytic Leukemia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

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Allogeneic transplantation

Allogeneic transplantation with matched unrelated donors

Intervention Type PROCEDURE

Other Intervention Names

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MUD transplant

Eligibility Criteria

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Inclusion Criteria

* \> 18 years of Age
* \< 70 years
* ECOG performance status 0, 1 or 2
* Left Ventricular Ejection Fraction \> 30%
* Creatinine clearance \> 40ml/min
* Transaminases \< 2X normal
* Total bilirubin \< 2X normal
* HIV seronegativity
* Weight \< 70kg for cord blood transplantation
* Ability to cover the cost of the transplant, necessary medications, and transportation/housing.
* Caregiver must be available while outpatient