Dehydroepiandrosterone (DHEA) Against Vaginal Atrophy

NCT ID: NCT01358760

Last Updated: 2017-06-12

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

450 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2012-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this Phase III trial is to evaluate the efficacy of intravaginal dehydroepiandrosterone (DHEA) in postmenopausal women with vaginal atrophy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vaginal Atrophy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo vaginal suppository

0.25% DHEA

Group Type EXPERIMENTAL

DHEA

Intervention Type DRUG

Vaginal suppository containing 0.25% (3.25 mg) DHEA

0.5% DHEA

Group Type EXPERIMENTAL

DHEA

Intervention Type DRUG

Vaginal suppository containing 0.5% (6.5 mg) DHEA

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Placebo

Placebo vaginal suppository

Intervention Type DRUG

DHEA

Vaginal suppository containing 0.25% (3.25 mg) DHEA

Intervention Type DRUG

DHEA

Vaginal suppository containing 0.5% (6.5 mg) DHEA

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Prasterone, Dehydroepiandrosterone Prasterone, Dehydroepiandrosterone

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Postmenopausal women (non-hysterectomized or hysterectomized)
* Women between 40 and 75 years of age
* Willing to participate in the study and sign an informed consent
* Women who have self-identified symptom(s) of vaginal atrophy
* For non-hysterectomized women, willing to have endometrial biopsy at baseline and end of study

Exclusion Criteria

* Undiagnosed abnormal genital bleeding
* Hypertension equal to or above 140/90 mm Hg
* The administration of any investigational drug within 30 days of screening visit
* Endometrial hyperplasia, cancer or endometrial histology showing proliferative, secretory or menstrual type characteristics at histologic evaluation of endometrial biopsy performed at screening
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

EndoCeutics Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

David Archer, MD

Role: PRINCIPAL_INVESTIGATOR

Clinical Research Center, Eastern Virginia Medical School, Norfolk, VA

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

EndoCeutics site # 39

Montgomery, Alabama, United States

Site Status

EndoCeutics site # 14

Tucson, Arizona, United States

Site Status

EndoCeutics site # 65

Little Rock, Arkansas, United States

Site Status

EndoCeutics site # 21

Sacramento, California, United States

Site Status

EndoCeutics site # 30

San Diego, California, United States

Site Status

EndoCeutics site # 36

Denver, Colorado, United States

Site Status

EndoCeutics site # 52

Denver, Colorado, United States

Site Status

EndoCeutics site # 66

Danbury, Connecticut, United States

Site Status

EndoCeutics site # 42

Milford, Connecticut, United States

Site Status

EndoCeutics site # 57

West Hartford, Connecticut, United States

Site Status

EndoCeutics site # 61

Newark, Delaware, United States

Site Status

EndoCeutics site # 26

Jacksonville, Florida, United States

Site Status

EndoCeutics site # 60

Lake Worth, Florida, United States

Site Status

EndoCeutics site # 54

North Miami, Florida, United States

Site Status

EndoCeutics site # 56

Pinellas Park, Florida, United States

Site Status

EndoCeutics site # 23

Sandy Springs, Georgia, United States

Site Status

EndoCeutics site # 10

Meridian, Idaho, United States

Site Status

EndoCeutics site # 55

Wichita, Kansas, United States

Site Status

EndoCeutics site # 27

Baltimore, Maryland, United States

Site Status

EndoCeutics site # 24

Omaha, Nebraska, United States

Site Status

EndoCeutics site # 50

Neptune City, New Jersey, United States

Site Status

EndoCeutics site # 33

Beachwood, Ohio, United States

Site Status

EndoCeutics site # 05

Cleveland, Ohio, United States

Site Status

EndoCeutics site # 47

Cleveland, Ohio, United States

Site Status

EndoCeutics site # 15

Columbus, Ohio, United States

Site Status

EndoCeutics site # 62

Providence, Rhode Island, United States

Site Status

EndoCeutics site # 64

Jackson, Tennessee, United States

Site Status

EndoCeutics site # 63

Memphis, Tennessee, United States

Site Status

EndoCeutics site # 53

San Antonio, Texas, United States

Site Status

EndoCeutics site # 51

Sandy City, Utah, United States

Site Status

EndoCeutics site # 09

West Jordan, Utah, United States

Site Status

EndoCeutics site # 03

Norfolk, Virginia, United States

Site Status

EndoCeutics site # 13

Calgary, Alberta, Canada

Site Status

EndoCeutics site # 06

Bathurst, New Brunswick, Canada

Site Status

EndoCeutics site # 59

Toronto, Ontario, Canada

Site Status

EndoCeutics site # 04

Drummondville, Quebec, Canada

Site Status

EndoCeutics site # 12

Montreal, Quebec, Canada

Site Status

EndoCeutics site # 02

Québec, Quebec, Canada

Site Status

EndoCeutics site # 01

Québec, Quebec, Canada

Site Status

EndoCeutics site # 18

Saint Romuald, Quebec, Canada

Site Status

EndoCeutics site # 08

Shawinigan, Quebec, Canada

Site Status

EndoCeutics site # 11

Sherbrooke, Quebec, Canada

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada

References

Explore related publications, articles, or registry entries linked to this study.

Bouchard C, Labrie F, Archer DF, Portman DJ, Koltun W, Elfassi E, Grainger DA, Ayotte N, Cooper TA, Martens M, Waldbaum AS, Labrie C, Cote I, Lavoie L, Martel C, Balser J; VVA Prasterone Group. Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy. Climacteric. 2015;18(4):590-607. doi: 10.3109/13697137.2014.992012. Epub 2015 Mar 3.

Reference Type RESULT
PMID: 25511551 (View on PubMed)

Portman DJ, Labrie F, Archer DF, Bouchard C, Cusan L, Girard G, Ayotte N, Koltun W, Blouin F, Young D, Wade A, Martel C, Dube R; other participating members of VVA Prasterone Group. Lack of effect of intravaginal dehydroepiandrosterone (DHEA, prasterone) on the endometrium in postmenopausal women. Menopause. 2015 Dec;22(12):1289-95. doi: 10.1097/GME.0000000000000470.

Reference Type RESULT
PMID: 25968836 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ERC-234

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Vaginal DHEA for Women After Breast Cancer
NCT01724242 WITHDRAWN PHASE2/PHASE3